Bhlha15 basic helix-loop-helix family, member a15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bhlha15provided by RGD
Official Full Name: basic helix-loop-helix family, member a15provided by RGD
Primary source: RGD:3091
See related: AllianceGenome:RGD:3091
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: bHlH; Mist1; Bhlhb8
Summary: Enables DNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of myotube differentiation; and neuron differentiation. Predicted to act upstream of or within several processes, including cell-cell adhesion mediated by cadherin; intracellular distribution of mitochondria; and type B pancreatic cell maturation. Located in nucleus. Orthologous to human BHLHA15 (basic helix-loop-helix family member a15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 17.0), Liver (RPKM 10.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12p11

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (15534123..15538299, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (10420465..10424641, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (12403385..12409103, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Mist1 activates exocrine-specific gene transcription through an acetylation mechanism.
Title: The bHLH domain of Mistl is sufficient to activate gene transcription.
bHLH regulate ABP in differentiated Sertoli cells.
Title: Role of basic helix-loop-helix (bHLH) and CREB transcription factors in the regulation of Sertoli cell androgen-binding protein expression.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D12Wox19 (e-PCR)
- UniSTS:518932

D12Wox20 (e-PCR)
- UniSTS:519009

D12Wox29 (e-PCR)
- UniSTS:518760

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables E-box binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in axon development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell adhesion mediated by cadherin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum unfolded protein response	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum unfolded protein response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of localization in cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glandular epithelial cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular distribution of mitochondria	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within localization of cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of myotube differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within type B pancreatic cell maturation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: class A basic helix-loop-helix protein 15

Names: Basic helix-loop-helix transcription factor (bHlH); MIST-1; basic helix-loop-helix domain containing, class B, 8; class B basic helix-loop-helix protein 8; muscle, intestine and stomach expression 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012863.2 → NP_036995.1 class A basic helix-loop-helix protein 15

See identical proteins and their annotated locations for NP_036995.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000012

UniProtKB/Swiss-Prot

P70562

UniProtKB/TrEMBL

A0A8L2QJ40, A6K1I0

Conserved Domains (1) summary

cd00083
Location:70 → 124

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...