Cenpe centromere protein E [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cenpeprovided by RGD
Official Full Name: centromere protein Eprovided by RGD
Primary source: RGD:1307115
See related: EnsemblRapid:ENSRNOG00000009339 AllianceGenome:RGD:1307115
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including kinetochore binding activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including chromosome organization; positive regulation of protein kinase activity; and regulation of chromosome segregation. Predicted to act upstream of or within regulation of protein stability and spindle assembly involved in female meiosis I. Predicted to be located in several cellular components, including kinetochore; midbody; and spindle. Predicted to be part of outer kinetochore. Predicted to be active in microtubule. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 13. Orthologous to human CENPE (centromere protein E). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 105.0), Spleen (RPKM 69.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q43

Exon count:: 46

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (226310970..226369636)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (223637035..223695692)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (240395974..240454785)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I.
Title: Kinesin-7 CENP-E mediates chromosome alignment and spindle assembly checkpoint in meiosis I.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinetochore binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule motor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in kinetochore assembly	ISO Inferred from Sequence Orthology more info
involved_in lateral attachment of mitotic spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in microtubule plus-end directed mitotic chromosome migration	ISO Inferred from Sequence Orthology more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in mitotic chromosome movement towards spindle pole	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromosome segregation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of developmental process	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic metaphase/anaphase transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein stability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spindle assembly involved in female meiosis I	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in condensed chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore microtubule	ISO Inferred from Sequence Orthology more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of outer kinetochore	ISO Inferred from Sequence Orthology more info
located_in spindle midzone	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: centromere-associated protein E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421086.1 → NP_001408015.1 centromere-associated protein E

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

D3ZV60

Related

ENSRNOP00000032795.6, ENSRNOT00000034565.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

226310970..226369636

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063282221.1 → XP_063138291.1 centromere-associated protein E isoform X3

UniProtKB/TrEMBL

D3ZV60
XM_006233351.4 → XP_006233413.3 centromere-associated protein E isoform X2

UniProtKB/TrEMBL

D3ZV60

Conserved Domains (2) summary

COG1196
Location:787 → 1710

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01374
Location:6 → 329

KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup
XM_039103858.2 → XP_038959786.1 centromere-associated protein E isoform X1

UniProtKB/TrEMBL

A0A8I6AVR3, D3ZV60

Related

ENSRNOP00000092498.2, ENSRNOT00000102011.2

Conserved Domains (3) summary

COG1196
Location:762 → 1631

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR04523
Location:1415 → 2009

Mplasa_alph_rch; helix-rich Mycoplasma protein

cd01374
Location:6 → 329

KISc_CENP_E; Kinesin motor domain, CENP-E/KIP2-like subgroup