Adrm1 ADRM1 26S proteasome ubiquitin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Adrm1provided by RGD
Official Full Name: ADRM1 26S proteasome ubiquitin receptorprovided by RGD
Primary source: RGD:69248
See related: EnsemblRapid:ENSRNOG00000055984 AllianceGenome:RGD:69248
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gp110
Summary: Predicted to enable several functions, including endopeptidase activator activity; protease binding activity; and proteasome binding activity. Predicted to be involved in several processes, including germ cell development; gonad development; and positive regulation of growth hormone receptor signaling pathway. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of proteasome regulatory particle, lid subcomplex. Orthologous to human ADRM1 (ADRM1 26S proteasome ubiquitin receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 138.0), Muscle (RPKM 135.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q43

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (187643043..187647805)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (167265435..167270197)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (175548181..175552943)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128438 (e-PCR)
- UniSTS:211746

D1S3695 (e-PCR)
- UniSTS:474273

AU043535 (e-PCR)
- UniSTS:159148

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopeptidase activator activity	IEA Inferred from Electronic Annotation more info
enables endopeptidase activator activity	ISO Inferred from Sequence Orthology more info
enables endopeptidase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables molecular function inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protease binding	IEA Inferred from Electronic Annotation more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info
enables proteasome binding	IEA Inferred from Electronic Annotation more info
enables proteasome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Sertoli cell development	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in follicle-stimulating hormone signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	ISO Inferred from Sequence Orthology more info
involved_in ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proteasome assembly	IEA Inferred from Electronic Annotation more info
involved_in proteasome assembly	ISO Inferred from Sequence Orthology more info
involved_in proteasome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in seminiferous tubule development	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	ISO Inferred from Sequence Orthology more info
involved_in thymus development	ISO Inferred from Sequence Orthology more info
involved_in transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome regulatory particle, lid subcomplex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: proteasomal ubiquitin receptor ADRM1

Names: 110 kDa cell membrane glycoprotein; ARM-1; adhesion regulating molecule 1; cell membrane glycoprotein, 110000M(r) (surface antigen); glycoprotein 110; rpn13 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031708.1 → NP_113896.1 proteasomal ubiquitin receptor ADRM1

See identical proteins and their annotated locations for NP_113896.1

Status: PROVISIONAL

Source sequence(s)

AB032742

UniProtKB/Swiss-Prot

Q6P795, Q9JMB5

UniProtKB/TrEMBL

A6KMB4

Related

ENSRNOP00000086833.1, ENSRNOT00000119821.2

Conserved Domains (2) summary

cd13314
Location:24 → 128

PH_Rpn13; Pleckstrin homology-like domain of Regulatory Particle Non-ATPase 13

pfam16550
Location:274 → 381

RPN13_C; UCH-binding domain