Nfkbib NFKB inhibitor beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nfkbibprovided by RGD
Official Full Name: NFKB inhibitor betaprovided by RGD
Primary source: RGD:621887
See related: EnsemblRapid:ENSRNOG00000020063 AllianceGenome:RGD:621887
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NF-kappaB binding activity. Involved in cytoplasmic sequestering of NF-kappaB. Predicted to be located in cytoplasm and nucleus. Predicted to be part of I-kappaB/NF-kappaB complex. Orthologous to human NFKBIB (NFKB inhibitor beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 86.7), Adrenal (RPKM 58.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (93173817..93181387, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (84046292..84053862, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (86941073..86948845, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate an increase in articular cavity inflammation in rats with osteoarthritis (OA) in the presence of miR-20a by targeting on NFKB inhibitor beta (IkappaBbeta) and activating the NF-kappa B (NF-kappaB) signaling pathway.
Title: miR-20a regulates inflammatory in osteoarthritis by targeting the IκBβ and regulates NK-κB signaling pathway activation.
Data suggest that RSK1 directly phosphorylates IkappaBbeta and contributes to the persistent activation of NF-kappaB by IL-1beta.
Title: Ribosomal S6 kinase-1 modulates interleukin-1beta-induced persistent activation of NF-kappaB through phosphorylation of IkappaBbeta.

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NF-kappa-B inhibitor beta

Names: I-kappa-B-beta; NF-kappa-BIB; ikB-B; ikB-beta; ikappaBbeta; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, beta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030867.2 → NP_110494.2 NF-kappa-B inhibitor beta

See identical proteins and their annotated locations for NP_110494.2

Status: PROVISIONAL

Source sequence(s)

BC085729

UniProtKB/Swiss-Prot

Q9JIA3

UniProtKB/TrEMBL

Q5U342

Related

ENSRNOP00000086277.2, ENSRNOT00000098249.2

Conserved Domains (3) summary

PHA03095
Location:203 → 298

PHA03095; ankyrin-like protein; Provisional

COG0666
Location:57 → 148

ANKYR; Ankyrin repeat [Signal transduction mechanisms]

sd00045
Location:206 → 237

ANK; ANK repeat [structural motif]