Mlst8 MTOR associated protein, LST8 homolog [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mlst8provided by RGD
Official Full Name: MTOR associated protein, LST8 homologprovided by RGD
Primary source: RGD:69242
See related: EnsemblRapid:ENSRNOG00000009667 AllianceGenome:RGD:69242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gbl
Summary: Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in TORC1 signaling; positive regulation of TOR signaling; and regulation of actin cytoskeleton organization. Predicted to act upstream of or within positive regulation of actin filament polymerization and positive regulation of peptidyl-tyrosine phosphorylation. Located in cytoplasm. Orthologous to human MLST8 (MTOR associated protein, LST8 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 67.5), Adrenal (RPKM 55.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q12

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (14002927..14008678, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (13498377..13504128, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (13839250..13845001, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results disclosed that, under endoplasmic reticulum stress conditions, mTORC1 causes apoptosis through suppression of Akt and consequent induction of the IRE1-JNK pathway.
Title: mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein serine/threonine kinase activator activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TOR signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in TORC1 signaling	IEA Inferred from Electronic Annotation more info
involved_in TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC2 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info
part_of TORC1 complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: target of rapamycin complex subunit LST8

Names: G beta-like protein; TORC subunit LST8; mammalian lethal with SEC13 protein 8; protein GbetaL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022404.2 → NP_071799.2 target of rapamycin complex subunit LST8

See identical proteins and their annotated locations for NP_071799.2

Status: VALIDATED

Source sequence(s)

BC097319, JAXUCZ010000010

UniProtKB/Swiss-Prot

Q4QRA0, Q9Z2K5

UniProtKB/TrEMBL

A0A8I5ZL90, A6HCT2

Related

ENSRNOP00000078598.1, ENSRNOT00000101517.2

Conserved Domains (2) summary

cd00200
Location:14 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:47 → 83

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

14002927..14008678 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017597522.3 → XP_017453011.1 target of rapamycin complex subunit LST8 isoform X1

UniProtKB/Swiss-Prot

Q4QRA0, Q9Z2K5

UniProtKB/TrEMBL

A0A8I5ZL90, A6HCT2

Conserved Domains (2) summary

cd00200
Location:14 → 297

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:47 → 83

7WD40; WD40 repeat [structural motif]