Inhbc inhibin subunit beta C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Inhbcprovided by RGD
Official Full Name: inhibin subunit beta Cprovided by RGD
Primary source: RGD:621194
See related: EnsemblRapid:ENSRNOG00000007700 AllianceGenome:RGD:621194
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine activity. Predicted to be involved in signal transduction. Predicted to be active in extracellular space. Orthologous to human INHBC (inhibin subunit beta C). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 259.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (65069450..65082919, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (63184141..63197630, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70648005..70661475, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The potential mechanism of INHBC and CSF1R in diabetic nephropathy.
Title: The potential mechanism of INHBC and CSF1R in diabetic nephropathy.
Data suggest that betaA- and betaC-activin subunit proteins and follistatin are autocrine growth regulators in regenerating liver and when expressed independently lead to hepatocyte apoptosis or mitosis in a subset of hepatocytes.
Title: betaA- and betaC-activin, follistatin, activin receptor mRNA and betaC-activin peptide expression during rat liver regeneration.
These results indicate that liver regeneration is accelerated in activin betaC-overexpressing liver, and that betaC may function to promote replication of hepatocytes during liver regeneration.
Title: Adenovirus-mediated overexpression of the activin betaC subunit accelerates liver regeneration in partially hepatectomized rats.
first report of a biological activity of activin C and E supports an involvement in liver tissue homeostasis
Title: Overexpression of activin beta(C) or activin beta(E) in the mouse liver inhibits regenerative deoxyribonucleic acid synthesis of hepatic cells.
Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers.
Title: Expression and dimerization of the rat activin subunits betaC and betaE: evidence for the ormation of novel activin dimers.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: inhibin beta C chain

Names: activin beta-C chain; activin/inhibin beta C; inhibin beta C subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022614.2 → NP_072136.1 inhibin beta C chain precursor

See identical proteins and their annotated locations for NP_072136.1

Status: PROVISIONAL

Source sequence(s)

BC089799

UniProtKB/Swiss-Prot

Q5FVS9, Q9WUK5

UniProtKB/TrEMBL

A6HQV4

Related

ENSRNOP00000010240.3, ENSRNOT00000010240.7

Conserved Domains (1) summary

cd19406
Location:246 → 351

TGF_beta_INHBC_E; transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins