Heg1 heart development protein with EGF-like domains 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Heg1provided by RGD
Official Full Name: heart development protein with EGF-like domains 1provided by RGD
Primary source: RGD:1564641
See related: EnsemblRapid:ENSRNOG00000001793 AllianceGenome:RGD:1564641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564641
Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including negative regulation of Rho protein signal transduction; negative regulation of Rho-dependent protein serine/threonine kinase activity; and negative regulation of membrane permeability. Predicted to act upstream of or within several processes, including circulatory system development; endothelial cell morphogenesis; and lymph circulation. Predicted to be located in cell-cell junction and external side of plasma membrane. Orthologous to human HEG1 (heart development protein with EGF like domains 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 401.2), Heart (RPKM 278.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (80512096..80600150, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (67006954..67095020, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (70234248..70322966, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delta-1/Notch-2/Hes-1 signaling pathway may regulate the regeneration and proliferation of renal tubules during acute kidney injury.
Title: Expression and function of the Delta-1/Notch-2/Hes-1 pathway during experimental acute kidney injury.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cardiac atrium morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell junction organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endothelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymph circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymph vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of membrane permeability	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pericardium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of fibroblast growth factor production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell junction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of body fluid levels	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within venous blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular trabecula myocardium morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein HEG homolog 1

Names: HEG homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.