Il17ra interleukin 17 receptor A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il17raprovided by RGD
Official Full Name: interleukin 17 receptor Aprovided by RGD
Primary source: RGD:1306559
See related: EnsemblRapid:ENSRNOG00000011153 AllianceGenome:RGD:1306559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Il17r
Summary: Predicted to enable interleukin-17 receptor activity and signaling receptor binding activity. Involved in cellular response to cytokine stimulus. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 51. Orthologous to human IL17RA (interleukin 17 receptor A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 301.8), Thymus (RPKM 211.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (155339742..155362382)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (153667534..153690174)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (152995865..153018394)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings demonstrate that IL-17 regulates SHP-2 expression and IL-17RA/STAT-3 dependent production of Cyr61, IL-23, GM-CSF and RANKL in AA-FLS and may reveal a new insight into the pathogenesis of RA.
Title: Interleukin 17 regulates SHP-2 and IL-17RA/STAT-3 dependent Cyr61, IL-23 and GM-CSF expression and RANKL mediated osteoclastogenesis by fibroblast-like synoviocytes in rheumatoid arthritis.
Down-regulation of the IL-17RA receptor by shRNA decreased IL-6 expression induced by IL-17A via p38 MAPK and ERK1/2 phosphorylation in HSCs
Title: Lentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6.
Members of the IL-17 family were localized in chondrocytes in the fracture callus. It parallels the localization of these cytokines and their receptors in chondrocytes during an endochondral differentiation program in the epiphyseal growth plate.
Title: Immunolocalization of IL-17A, IL-17B, and their receptors in chondrocytes during fracture healing.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables interleukin-17 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-17 receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T-helper 17 type immune response	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to fungus	ISO Inferred from Sequence Orthology more info
involved_in fibroblast activation	ISO Inferred from Sequence Orthology more info
involved_in granulocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in interleukin-17-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-17A-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-23 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-17 receptor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107883.2 → NP_001101353.2 interleukin-17 receptor A precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A6ILA4, D4A740

Related

ENSRNOP00000014885.7, ENSRNOT00000014885.8

Conserved Domains (3) summary

pfam08357
Location:380 → 539

SEFIR; SEFIR domain

pfam16556
Location:48 → 198

IL17R_fnIII_D1; Interleukin-17 receptor, fibronectin-III-like domain 1

pfam16578
Location:199 → 303

IL17R_fnIII_D2; Interleukin 17 receptor D