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    Dpp8 dipeptidylpeptidase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315758, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dpp8provided by RGD
    Official Full Name
    dipeptidylpeptidase 8provided by RGD
    Primary source
    RGD:1310901
    See related
    EnsemblRapid:ENSRNOG00000019105 AllianceGenome:RGD:1310901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in negative regulation of programmed cell death and proteolysis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human DPP8 (dipeptidyl peptidase 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 407.7), Kidney (RPKM 261.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dpp8 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (74445815..74501017)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (65550620..65605828)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (70521782..70576180)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene integrator complex subunit 14 Neighboring gene 3-hydroxyacyl-CoA dehydratase 3 Neighboring gene ATP synthase membrane subunit DAPIT, mitochondrial-like Neighboring gene immunoglobulin superfamily, DCC subclass, member 4 Neighboring gene peptidyl-prolyl cis-trans isomerase NIMA-interacting 4-like Neighboring gene immunoglobulin superfamily, DCC subclass, member 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues. Harstad EB, et al. Regul Pept, 2013 Sep 10. PMID 23850796
    2. Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues. Dubois V, et al. J Histochem Cytochem, 2009 Jun. PMID 19188489, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DPP8 and DPP9 may act similarly across tissues, and that their actions might in part overlap with DPP4.
      Title: DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues.
    2. We showed the expression of DPP8 and DPP9 in the testis, epididymis, and sperm.
      Title: Enzyme activity and immunohistochemical localization of dipeptidyl peptidase 8 and 9 in male reproductive tissues.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidyl-peptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dipeptidyl-peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dipeptidyl peptidase 8
    NP_001381020.1
    NP_001381021.1
    NP_001381022.1
    XP_006243316.1
    XP_006243318.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394091.1 → NP_001381020.1  dipeptidyl peptidase 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J5D8, D3ZHQ1
      Related
      ENSRNOP00000084987.2, ENSRNOT00000111343.2
      Conserved Domains (2) summary
      pfam00326
      Location:680 → 885
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:169 → 589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    2. NM_001394092.1 → NP_001381021.1  dipeptidyl peptidase 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6J5D8, D3ZHQ1
      Conserved Domains (2) summary
      pfam00326
      Location:680 → 885
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:169 → 589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    3. NM_001394093.1 → NP_001381022.1  dipeptidyl peptidase 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      Conserved Domains (2) summary
      pfam00326
      Location:671 → 876
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:160 → 580
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

    RNA

    1. NR_172080.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      74445815..74501017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243256.5 → XP_006243318.1  dipeptidyl peptidase 8 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A305, A6J5D9
      Conserved Domains (2) summary
      pfam00930
      Location:169 → 589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
      cl21494
      Location:680 → 716
      Abhydrolase; alpha/beta hydrolases

    2. XM_006243254.3 → XP_006243316.1  dipeptidyl peptidase 8 isoform X1

      See identical proteins and their annotated locations for XP_006243316.1

      UniProtKB/TrEMBL
      A6J5D8, D3ZHQ1
      Conserved Domains (2) summary
      pfam00326
      Location:680 → 885
      Peptidase_S9; Prolyl oligopeptidase family
      pfam00930
      Location:169 → 589
      DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    Nucleotide Protein Strain
    Heading Accession and Version

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