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    ZBTB25 zinc finger and BTB domain containing 25 [ Homo sapiens (human) ]

    Gene ID: 7597, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZBTB25provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 25provided by HGNC
    Primary source
    HGNC:HGNC:13112
    See related
    Ensembl:ENSG00000089775 MIM:194541; AllianceGenome:HGNC:13112
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KUP; ZNF46; C14orf51
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver (RPKM 4.4), thyroid (RPKM 2.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZBTB25 in Genome Data Viewer
    Location:
    14q23.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64449106..64505213, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (58629558..58712973, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64915824..64971931, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903328 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8523 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8525 Neighboring gene estrogen receptor 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5832 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8526 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:64805694-64806376 Neighboring gene testis expressed 21, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8531 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr14:64858021-64858754 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:64858755-64859488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:64859797-64860574 Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene Sharpr-MPRA regulatory region 9441 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5834 Neighboring gene A-kinase anchoring protein 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8533 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8534 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8535 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64970928-64971598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5837 Neighboring gene HSPA2 and ZBTB1 antisense RNA 1 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5838 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8536 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5839 Neighboring gene heat shock protein family A (Hsp70) member 2 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:65039864-65040400 Neighboring gene protein phosphatase 1 regulatory subunit 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc Finger-Containing Cellular Transcription Corepressor ZBTB25 Promotes Influenza Virus RNA Transcription and Is a Target for Zinc Ejector Drugs. Chen SC, et al. J Virol, 2017 Oct 15. PMID 28768860, Free PMC Article
    2. Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor. Benita Y, et al. Blood, 2010 Jul 1. PMID 20410506, Free PMC Article
    3. E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro. Lear TB, et al. J Biol Chem, 2023 Dec. PMID 37890782, Free PMC Article
    4. The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. Chardin P, et al. Nucleic Acids Res, 1991 Apr 11. PMID 2027750, Free PMC Article
    5. Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy. Madhavan A, et al. mSphere, 2021 Feb 24. PMID 33627504, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro.
      Title: E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro.
    2. Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy.
      Title: Transcription Repressor Protein ZBTB25 Associates with HDAC1-Sin3a Complex in Mycobacterium tuberculosis-Infected Macrophages, and Its Inhibition Clears Pathogen by Autophagy.
    3. study demonstrates that ZBTB25 regulates IAV (Influenza A virus) RNA transcription and replication and serves as a promising antiviral target for IAV treatment.
      Title: Zinc Finger-Containing Cellular Transcription Corepressor ZBTB25 Promotes Influenza Virus RNA Transcription and Is a Target for Zinc Ejector Drugs.
    4. ZBTB25 functions as a negative regulator of nuclear factor of activated T cells (NF-AT) activation, such that RNA interference mediated knockdown resulted in enhanced activation of target genes.
      Title: Gene enrichment profiles reveal T-cell development, differentiation, and lineage-specific transcription factors including ZBTB25 as a novel NF-AT repressor.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 25
    Names
    zinc finger protein 46
    zinc finger protein KUP

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001304507.1 → NP_001291436.1  zinc finger and BTB domain-containing protein 25 isoform a

      See identical proteins and their annotated locations for NP_001291436.1

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
      Source sequence(s)
      AK098181, AL049869, BC014650, BQ446833, BX479957, DA328137
      Consensus CDS
      CCDS9765.1
      UniProtKB/Swiss-Prot
      B3KUX6, P24278, Q8IYH9
      Related
      ENSP00000378204.1, ENST00000394715.1
      Conserved Domains (3) summary
      sd00019
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 114
      BTB; BTB/POZ domain

    2. NM_001304508.1 → NP_001291437.1  zinc finger and BTB domain-containing protein 25 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL049869, BC014650
      Consensus CDS
      CCDS76689.1
      UniProtKB/TrEMBL
      G3V2K3
      Related
      ENSP00000450718.1, ENST00000555220.5
      Conserved Domains (1) summary
      pfam00651
      Location:14 → 60
      BTB; BTB/POZ domain

    3. NM_001354682.2 → NP_001341611.1  zinc finger and BTB domain-containing protein 25 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (c).
      Source sequence(s)
      AL049869, AL122035
      Conserved Domains (3) summary
      sd00019
      Location:279 → 299
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:279 → 299
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:53 → 153
      BTB; BTB/POZ domain

    4. NM_001354683.2 → NP_001341612.1  zinc finger and BTB domain-containing protein 25 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL049869
      Conserved Domains (3) summary
      sd00019
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 114
      BTB; BTB/POZ domain

    5. NM_001354684.2 → NP_001341613.1  zinc finger and BTB domain-containing protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
      Source sequence(s)
      AL049869, AL122035
      Consensus CDS
      CCDS9765.1
      UniProtKB/Swiss-Prot
      B3KUX6, P24278, Q8IYH9
      Conserved Domains (3) summary
      sd00019
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 114
      BTB; BTB/POZ domain

    6. NM_001354685.2 → NP_001341614.1  zinc finger and BTB domain-containing protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
      Source sequence(s)
      AL049869, AL122035
      Consensus CDS
      CCDS9765.1
      UniProtKB/Swiss-Prot
      B3KUX6, P24278, Q8IYH9
      Conserved Domains (3) summary
      sd00019
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 114
      BTB; BTB/POZ domain

    7. NM_001354686.2 → NP_001341615.1  zinc finger and BTB domain-containing protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
      Source sequence(s)
      AL049869, AL122035
      Consensus CDS
      CCDS9765.1
      UniProtKB/Swiss-Prot
      B3KUX6, P24278, Q8IYH9
      Conserved Domains (3) summary
      sd00019
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 114
      BTB; BTB/POZ domain

    8. NM_001354687.2 → NP_001341616.1  zinc finger and BTB domain-containing protein 25 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
      Source sequence(s)
      AL049869, AL122035
      Consensus CDS
      CCDS9765.1
      UniProtKB/Swiss-Prot
      B3KUX6, P24278, Q8IYH9
      Conserved Domains (3) summary
      sd00019
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 114
      BTB; BTB/POZ domain

    9. NM_006977.5 → NP_008908.2  zinc finger and BTB domain-containing protein 25 isoform a

      See identical proteins and their annotated locations for NP_008908.2

      Status: VALIDATED

      Description
      Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
      Source sequence(s)
      AL049869, AL122035, BC035804, BQ446833, BX479957, DA328137
      Consensus CDS
      CCDS9765.1
      UniProtKB/Swiss-Prot
      B3KUX6, P24278, Q8IYH9
      Related
      ENSP00000476746.1, ENST00000608382.6
      Conserved Domains (3) summary
      sd00019
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:240 → 260
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:14 → 114
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      64449106..64505213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047431770.1 → XP_047287726.1  zinc finger and BTB domain-containing protein 25 isoform X1

    RNA

    1. XR_943522.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      58629558..58712973 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376710.1 → XP_054232685.1  zinc finger and BTB domain-containing protein 25 isoform X3

    2. XM_054376709.1 → XP_054232684.1  zinc finger and BTB domain-containing protein 25 isoform X1

    3. XM_054376708.1 → XP_054232683.1  zinc finger and BTB domain-containing protein 25 isoform X2

    RNA

    1. XR_008488894.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24278.2 GenPept UniProtKB/Swiss-Prot:P24278

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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