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    GPR35 G protein-coupled receptor 35 [ Homo sapiens (human) ]

    Gene ID: 2859, updated on 27-Nov-2024

    Summary

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    Official Symbol
    GPR35provided by HGNC
    Official Full Name
    G protein-coupled receptor 35provided by HGNC
    Primary source
    HGNC:HGNC:4492
    See related
    Ensembl:ENSG00000178623 MIM:602646; AllianceGenome:HGNC:4492
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Enables C-X-C chemokine receptor activity. Involved in chemokine-mediated signaling pathway; negative regulation of voltage-gated calcium channel activity; and positive regulation of cytosolic calcium ion concentration. Located in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in duodenum (RPKM 17.7), small intestine (RPKM 16.7) and 7 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See GPR35 in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240605430..240633159)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241099521..241129422)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241544847..241572576)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17404 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17405 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17406 Neighboring gene Sharpr-MPRA regulatory region 5965 Neighboring gene CAPN10 divergent transcript Neighboring gene calpain 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17407 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241564851-241565357 Neighboring gene Sharpr-MPRA regulatory region 3769 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241571415-241571915 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241581025-241581562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241584497-241584996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12522 Neighboring gene uncharacterized LOC124908016 Neighboring gene galactose-3-O-sulfotransferase 1 pseudogene Neighboring gene aquaporin 12B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. G-Protein-Coupled Receptor 35 Mediates Human Saphenous Vein Vascular Smooth Muscle Cell Migration and Endothelial Cell Proliferation. McCallum JE, et al. J Vasc Res, 2015. PMID 27064272, Free PMC Article
    2. Human bone marrow lymphocytes. Cytotoxic effector cells in the bone marrow of normal individuals. Fauci AS, et al. J Clin Invest, 1976 Apr. PMID 947955, Free PMC Article
    3. Cloning of a G-protein-coupled receptor that shows an activity to transform NIH3T3 cells and is expressed in gastric cancer cells. Okumura S, et al. Cancer Sci, 2004 Feb. PMID 14965362, Free PMC Article
    4. GPR35 is a novel lysophosphatidic acid receptor. Oka S, et al. Biochem Biophys Res Commun, 2010 Apr 30. PMID 20361937
    5. Expression of functional GPR35 in human iNKT cells. Fallarini S, et al. Biochem Biophys Res Commun, 2010 Jul 30. PMID 20599711

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPR35 acts a dual role and therapeutic target in inflammation.
      Title: GPR35 acts a dual role and therapeutic target in inflammation.
    2. Increased GPR35 expression in human colorectal and pancreatic cancer samples: A preliminary clinical validation of a new biomarker.
      Title: Increased GPR35 expression in human colorectal and pancreatic cancer samples: A preliminary clinical validation of a new biomarker.
    3. Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand.
      Title: Recent advances in GPR35 pharmacology; 5-HIAA serotonin metabolite becomes a ligand.
    4. Involvement of CXCL17 and GPR35 in Gastric Cancer Initiation and Progression.
      Title: Involvement of CXCL17 and GPR35 in Gastric Cancer Initiation and Progression.
    5. Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
      Title: Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
    6. The GPR35 expression pattern is associated with overall survival in male patients with colorectal cancer.
      Title: The GPR35 expression pattern is associated with overall survival in male patients with colorectal cancer.
    7. Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma.
      Title: Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma.
    8. GPR35 in Intestinal Diseases: From Risk Gene to Function.
      Title: GPR35 in Intestinal Diseases: From Risk Gene to Function.
    9. GPR35 regulates osteogenesis via the Wnt/GSK3beta/beta-catenin signaling pathway.
      Title: GPR35 regulates osteogenesis via the Wnt/GSK3β/β-catenin signaling pathway.
    10. Inflammatory bowel disease susceptible gene GPR35 promotes bowel inflammation in mice.
      Title: Inflammatory bowel disease susceptible gene GPR35 promotes bowel inflammation in mice.
    Submit: New GeneRIF Correction See all GeneRIFs (28)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: CAPN10

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NOT enables C-X-C chemokine receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables C-X-C chemokine receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of voltage-gated calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 35
    Names
    KYNA receptor
    kynurenic acid receptor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195381.3 → NP_001182310.1  G-protein coupled receptor 35 isoform b

      See identical proteins and their annotated locations for NP_001182310.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC124862
      Consensus CDS
      CCDS56174.1
      UniProtKB/TrEMBL
      A8K2J1
      Conserved Domains (1) summary
      cd15164
      Location:74 → 318
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001195382.3 → NP_001182311.1  G-protein coupled receptor 35 isoform b

      See identical proteins and their annotated locations for NP_001182311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The resulting isoform (b, also known as GPR35b) is longer at the N-terminus, compared to isoform a. Variants 2-4 all encode the same isoform (b).
      Source sequence(s)
      AC124862
      Consensus CDS
      CCDS56174.1
      UniProtKB/TrEMBL
      A8K2J1
      Related
      ENSP00000411788.2, ENST00000430267.2
      Conserved Domains (1) summary
      cd15164
      Location:74 → 318
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001394730.1 → NP_001381659.1  G-protein coupled receptor 35 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC124862
      Consensus CDS
      CCDS56174.1
      UniProtKB/TrEMBL
      A8K2J1
      Conserved Domains (1) summary
      cd15164
      Location:74 → 318
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. NM_005301.5 → NP_005292.2  G-protein coupled receptor 35 isoform a

      See identical proteins and their annotated locations for NP_005292.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a, also known as GPR35a).
      Source sequence(s)
      AC124862
      Consensus CDS
      CCDS2541.1
      UniProtKB/Swiss-Prot
      J3KR30, O43495, Q17R58, Q4VBN5, Q4ZFV2, Q6FHI8, Q86UH4, Q9HC97
      UniProtKB/TrEMBL
      B2RA17
      Related
      ENSP00000384263.1, ENST00000407714.2
      Conserved Domains (1) summary
      pfam00001
      Location:43 → 276
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      240605430..240633159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      241099521..241129422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HC97.4 GenPept UniProtKB/Swiss-Prot:Q9HC97

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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