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    LURAP1L leucine rich adaptor protein 1 like [ Homo sapiens (human) ]

    Gene ID: 286343, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LURAP1Lprovided by HGNC
    Official Full Name
    leucine rich adaptor protein 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:31452
    See related
    Ensembl:ENSG00000153714 MIM:616130; AllianceGenome:HGNC:31452
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LRAP35b; bA3L8.2; C9orf150; HYST0841
    Summary
    Predicted to be involved in regulation of signal transduction. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta (RPKM 9.1), lung (RPKM 7.8) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See LURAP1L in Genome Data Viewer
    Location:
    9p23
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (12775020..12823060)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (12784296..12832387)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (12775019..12823059)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene LURAP1L antisense RNA 1 Neighboring gene tyrosinase related protein 1 Neighboring gene RNA, 7SL, cytoplasmic 849, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:12814001-12815200 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:12948228-12949066 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:12953525-12954183 Neighboring gene small nucleolar RNA, C/D box 137 Neighboring gene peroxiredoxin 1 pseudogene 1 Neighboring gene lupus La protein-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13037568-13038084

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. Lee ICJ, et al. J Biol Chem, 2014 Sep 26. PMID 25107909, Free PMC Article
    2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. Yamada S, et al. Oncogene, 2004 Aug 5. PMID 15221005
    3. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. Tomarev SI, et al. Invest Ophthalmol Vis Sci, 2003 Jun. PMID 12766061
    4. Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. Thiébaut R, et al. PLoS One, 2016. PMID 27812135, Free PMC Article
    5. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ38505, FLJ90271, MGC46502

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of canonical NF-kappaB signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leucine rich adaptor protein 1-like
    Names
    leucine repeat adaptor protein 35b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203403.2 → NP_981948.1  leucine rich adaptor protein 1-like

      Status: VALIDATED

      Source sequence(s)
      AK095824, BC036923, BE464662, BM739457, BX508229, CD678148
      Consensus CDS
      CCDS6473.1
      UniProtKB/Swiss-Prot
      Q5VZX7, Q8IV03, Q8N923, Q8NCG2
      Related
      ENSP00000321026.3, ENST00000319264.4
      Conserved Domains (1) summary
      pfam14854
      Location:83 → 193
      LURAP; Leucine rich adaptor protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      12775020..12823060
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005251443.4 → XP_005251500.1  leucine rich adaptor protein 1-like isoform X1

      Conserved Domains (1) summary
      pfam14854
      Location:83 → 105
      LURAP; Leucine rich adaptor protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      12784296..12832387
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362779.1 → XP_054218754.1  leucine rich adaptor protein 1-like isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IV03.3 GenPept UniProtKB/Swiss-Prot:Q8IV03

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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