ADGRL1 adhesion G protein-coupled receptor L1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ADGRL1provided by HGNC
Official Full Name: adhesion G protein-coupled receptor L1provided by HGNC
Primary source: HGNC:HGNC:20973
See related: Ensembl:ENSG00000072071 MIM:616416; AllianceGenome:HGNC:20973
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CL1; LEC2; CIRL1; LPHN1; DEDBANP
Summary: This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Expression: Broad expression in brain (RPKM 19.5), fat (RPKM 7.9) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.12

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (14147743..14206169, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (14274383..14332836, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (14258555..14316981, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.
Title: Dysfunction of the adhesion G protein-coupled receptor latrophilin 1 (ADGRL1/LPHN1) increases the risk of obesity.
ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
Title: ADGRL1 haploinsufficiency causes a variable spectrum of neurodevelopmental disorders in humans and alters synaptic activity and behavior in a mouse model.
results suggest that SSB splicing selectively affects the duality of LPHN1 signaling toward opposing cAMP pathways
Title: Alternative splicing event modifying ADGRL1/latrophilin-1 cytoplasmic tail promotes both opposing and dual cAMP signaling pathways.
Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.
Title: Cortisol facilitates the immune escape of human acute myeloid leukemia cells by inducing latrophilin 1 expression.
These findings reveal a novel mechanism of axonal pathfinding, whereby latrophilin-1 and Lasso mediate both short-range interaction that supports synaptogenesis, and long-range signaling that induces axonal attraction.
Title: Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.
alterations in latrophilin expression occur in AML cells expressing P-gp
Title: Overexpression of the ABCB1 drug transporter in acute myeloid leukemia cells is associated with downregulation of latrophilin-1.
Our findings demonstrate that latrophilin-1 could be considered as a novel biomarker of human acute myeloid leukaemia
Title: Expression of functional neuronal receptor latrophilin 1 in human acute myeloid leukaemia cells.
A single SNP in LPHN1 (rs3810256) was identified, with the minor allele increasing the risk of asthma.
Title: Latrophilin receptors: novel bronchodilator targets in asthma.
Data suggest teneurin-1/TENM1 (and possibly TENM3) undergoes proteolysis to TCAPs (teneurin C-terminal associated peptides) that form intercellular adhesive units with latrophilin; signaling via TENM1 TCAPs appears to regulate reproduction. [REVIEW]
Title: Role of the teneurins, teneurin C-terminal associated peptides (TCAP) in reproduction: clinical perspectives.
In this article they evaluated the amount of p120-p85 complex still presented on the cellular membrane and confirmed that on cell surface major amount of mature CIRL-1 presented as a p120-p85 subunit complex.
Title: Association of the subunits of the calcium-independent receptor of α-latrotoxin.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Developmental delay, behavioral abnormalities, and neuropsychiatric disorders MedGen: C5774224 OMIM: 620065 GeneReviews: Not available	not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH71187 (e-PCR)
- UniSTS:89349

G43524 (e-PCR)
- UniSTS:94981

LPHN1__6414 (e-PCR)
- UniSTS:468502

D19S706E (e-PCR)
- UniSTS:150606

A003B10 (e-PCR)
- UniSTS:3219

RH15904 (e-PCR)
- UniSTS:27601

Vsx1 (e-PCR), detects polymorphism
- UniSTS:233946

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info
enables latrotoxin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables latrotoxin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: adhesion G protein-coupled receptor L1

Names: CIRL-1; calcium-independent alpha-latrotoxin receptor 1; latrophilin-1; lectomedin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008701.3 → NP_001008701.1 adhesion G protein-coupled receptor L1 isoform 1 precursor

See identical proteins and their annotated locations for NP_001008701.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AB020628, AF307079, BC002974, BC072445

Consensus CDS

CCDS32928.1

UniProtKB/Swiss-Prot

O94910, Q96IE7, Q9BU07, Q9HAR3

Related

ENSP00000340688.5, ENST00000340736.10

Conserved Domains (8) summary

smart00303
Location:798 → 850

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:476 → 539

HormR; Domain present in hormone receptors

PHA03247
Location:398 → 482

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:857 → 1114

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1113 → 1474

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:549 → 774

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:142 → 398

OLF; Olfactomedin-like domain
NM_014921.5 → NP_055736.2 adhesion G protein-coupled receptor L1 isoform 2 precursor

See identical proteins and their annotated locations for NP_055736.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2) compared to isoform 1.

Source sequence(s)

AB020628, AF307079, BC002974, BC072445

Consensus CDS

CCDS12307.1

UniProtKB/Swiss-Prot

O94910

Related

ENSP00000355328.2, ENST00000361434.8

Conserved Domains (8) summary

smart00303
Location:793 → 845

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:471 → 534

HormR; Domain present in hormone receptors

PHA03247
Location:393 → 465

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:852 → 1109

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1108 → 1469

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:544 → 769

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:137 → 393

OLF; Olfactomedin-like domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

14147743..14206169 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047438418.1 → XP_047294374.1 adhesion G protein-coupled receptor L1 isoform X9
XM_005259818.4 → XP_005259875.1 adhesion G protein-coupled receptor L1 isoform X5

See identical proteins and their annotated locations for XP_005259875.1

Conserved Domains (8) summary

smart00303
Location:793 → 845

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:471 → 534

HormR; Domain present in hormone receptors

PHA03247
Location:393 → 465

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:852 → 1109

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1108 → 1493

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:544 → 769

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:137 → 393

OLF; Olfactomedin-like domain
XM_011527798.3 → XP_011526100.1 adhesion G protein-coupled receptor L1 isoform X3

See identical proteins and their annotated locations for XP_011526100.1

Conserved Domains (8) summary

smart00303
Location:800 → 852

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:478 → 541

HormR; Domain present in hormone receptors

PHA03247
Location:393 → 497

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:859 → 1116

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1115 → 1500

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:551 → 776

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:137 → 393

OLF; Olfactomedin-like domain
XM_011527796.3 → XP_011526098.1 adhesion G protein-coupled receptor L1 isoform X2

See identical proteins and their annotated locations for XP_011526098.1

Conserved Domains (8) summary

smart00303
Location:805 → 857

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:483 → 546

HormR; Domain present in hormone receptors

PHA03247
Location:398 → 502

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:864 → 1121

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1120 → 1505

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:556 → 781

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:142 → 398

OLF; Olfactomedin-like domain
XM_047438417.1 → XP_047294373.1 adhesion G protein-coupled receptor L1 isoform X8
XM_017026477.2 → XP_016881966.1 adhesion G protein-coupled receptor L1 isoform X4

Conserved Domains (8) summary

smart00303
Location:799 → 851

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:477 → 540

HormR; Domain present in hormone receptors

PHA03247
Location:399 → 471

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:858 → 1115

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1114 → 1499

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:550 → 775

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:143 → 399

OLF; Olfactomedin-like domain
XM_017026479.2 → XP_016881968.1 adhesion G protein-coupled receptor L1 isoform X7
XM_017026478.2 → XP_016881967.1 adhesion G protein-coupled receptor L1 isoform X6

Conserved Domains (8) summary

smart00303
Location:806 → 858

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:484 → 547

HormR; Domain present in hormone receptors

PHA03247
Location:399 → 537

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:865 → 1122

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1121 → 1482

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:557 → 782

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:143 → 399

OLF; Olfactomedin-like domain
XM_017026475.2 → XP_016881964.1 adhesion G protein-coupled receptor L1 isoform X1

Conserved Domains (8) summary

smart00303
Location:806 → 858

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:484 → 547

HormR; Domain present in hormone receptors

PHA03247
Location:399 → 503

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:865 → 1122

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1121 → 1506

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:557 → 782

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:143 → 399

OLF; Olfactomedin-like domain
XM_047438415.1 → XP_047294371.1 adhesion G protein-coupled receptor L1 isoform X5
XM_017026476.2 → XP_016881965.1 adhesion G protein-coupled receptor L1 isoform X1

Conserved Domains (8) summary

smart00303
Location:806 → 858

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:484 → 547

HormR; Domain present in hormone receptors

PHA03247
Location:399 → 503

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:865 → 1122

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1121 → 1506

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:557 → 782

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:143 → 399

OLF; Olfactomedin-like domain
XM_047438416.1 → XP_047294372.1 adhesion G protein-coupled receptor L1 isoform X5
XM_047438413.1 → XP_047294369.1 adhesion G protein-coupled receptor L1 isoform X1
XM_047438414.1 → XP_047294370.1 adhesion G protein-coupled receptor L1 isoform X3
XM_024451420.2 → XP_024307188.1 adhesion G protein-coupled receptor L1 isoform X1

Conserved Domains (8) summary

smart00303
Location:806 → 858

GPS; G-protein-coupled receptor proteolytic site domain

smart00008
Location:484 → 547

HormR; Domain present in hormone receptors

PHA03247
Location:399 → 503

PHA03247; large tegument protein UL36; Provisional

cd16007
Location:865 → 1122

7tmB2_Latrophilin-1; Latrophilin-1, member of the class B2 family of seven-transmembrane G protein-coupled receptors

pfam02140
Location:48 → 128

Gal_Lectin; Galactose binding lectin domain

pfam02354
Location:1121 → 1506

Latrophilin; Latrophilin Cytoplasmic C-terminal region

pfam16489
Location:557 → 782

GAIN; GPCR-Autoproteolysis INducing (GAIN) domain

cl02549
Location:143 → 399

OLF; Olfactomedin-like domain
XM_047438419.1 → XP_047294375.1 adhesion G protein-coupled receptor L1 isoform X12
XM_017026480.2 → XP_016881969.2 adhesion G protein-coupled receptor L1 isoform X11
XM_011527801.3 → XP_011526103.2 adhesion G protein-coupled receptor L1 isoform X10
XM_017026481.2 → XP_016881970.1 adhesion G protein-coupled receptor L1 isoform X13

Reference GRCh38.p14 PATCHES

Genomic

NW_021160022.1 Reference GRCh38.p14 PATCHES

Range

359902..418328 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054332684.1 → XP_054188659.1 adhesion G protein-coupled receptor L1 isoform X9
XM_054332679.1 → XP_054188654.1 adhesion G protein-coupled receptor L1 isoform X5
XM_054332675.1 → XP_054188650.1 adhesion G protein-coupled receptor L1 isoform X3
XM_054332674.1 → XP_054188649.1 adhesion G protein-coupled receptor L1 isoform X2
XM_054332683.1 → XP_054188658.1 adhesion G protein-coupled receptor L1 isoform X8
XM_054332677.1 → XP_054188652.1 adhesion G protein-coupled receptor L1 isoform X4
XM_054332682.1 → XP_054188657.1 adhesion G protein-coupled receptor L1 isoform X7
XM_054332681.1 → XP_054188656.1 adhesion G protein-coupled receptor L1 isoform X6
XM_054332670.1 → XP_054188645.1 adhesion G protein-coupled receptor L1 isoform X1
XM_054332678.1 → XP_054188653.1 adhesion G protein-coupled receptor L1 isoform X5
XM_054332672.1 → XP_054188647.1 adhesion G protein-coupled receptor L1 isoform X1
XM_054332680.1 → XP_054188655.1 adhesion G protein-coupled receptor L1 isoform X5
XM_054332673.1 → XP_054188648.1 adhesion G protein-coupled receptor L1 isoform X1
XM_054332676.1 → XP_054188651.1 adhesion G protein-coupled receptor L1 isoform X3
XM_054332671.1 → XP_054188646.1 adhesion G protein-coupled receptor L1 isoform X1
XM_054332687.1 → XP_054188662.1 adhesion G protein-coupled receptor L1 isoform X12
XM_054332686.1 → XP_054188661.1 adhesion G protein-coupled receptor L1 isoform X11
XM_054332685.1 → XP_054188660.1 adhesion G protein-coupled receptor L1 isoform X10
XM_054332688.1 → XP_054188663.1 adhesion G protein-coupled receptor L1 isoform X13

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

14274383..14332836 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054320219.1 → XP_054176194.1 adhesion G protein-coupled receptor L1 isoform X9
XM_054320214.1 → XP_054176189.1 adhesion G protein-coupled receptor L1 isoform X5
XM_054320210.1 → XP_054176185.1 adhesion G protein-coupled receptor L1 isoform X3
XM_054320209.1 → XP_054176184.1 adhesion G protein-coupled receptor L1 isoform X2
XM_054320218.1 → XP_054176193.1 adhesion G protein-coupled receptor L1 isoform X8
XM_054320212.1 → XP_054176187.1 adhesion G protein-coupled receptor L1 isoform X4
XM_054320217.1 → XP_054176192.1 adhesion G protein-coupled receptor L1 isoform X7
XM_054320216.1 → XP_054176191.1 adhesion G protein-coupled receptor L1 isoform X6
XM_054320205.1 → XP_054176180.1 adhesion G protein-coupled receptor L1 isoform X1
XM_054320213.1 → XP_054176188.1 adhesion G protein-coupled receptor L1 isoform X5
XM_054320207.1 → XP_054176182.1 adhesion G protein-coupled receptor L1 isoform X1
XM_054320215.1 → XP_054176190.1 adhesion G protein-coupled receptor L1 isoform X5
XM_054320208.1 → XP_054176183.1 adhesion G protein-coupled receptor L1 isoform X1
XM_054320211.1 → XP_054176186.1 adhesion G protein-coupled receptor L1 isoform X3
XM_054320206.1 → XP_054176181.1 adhesion G protein-coupled receptor L1 isoform X1
XM_054320222.1 → XP_054176197.1 adhesion G protein-coupled receptor L1 isoform X12
XM_054320221.1 → XP_054176196.1 adhesion G protein-coupled receptor L1 isoform X11
XM_054320220.1 → XP_054176195.1 adhesion G protein-coupled receptor L1 isoform X10
XM_054320223.1 → XP_054176198.1 adhesion G protein-coupled receptor L1 isoform X13