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    LINC01963 long intergenic non-protein coding RNA 1963 [ Homo sapiens (human) ]

    Gene ID: 150967, updated on 10-Dec-2024

    Summary

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    Official Symbol
    LINC01963provided by HGNC
    Official Full Name
    long intergenic non-protein coding RNA 1963provided by HGNC
    Primary source
    HGNC:HGNC:25283
    See related
    Ensembl:ENSG00000260804 AllianceGenome:HGNC:25283
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PKI55
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    Genomic context

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    See LINC01963 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216216889..216220192)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (216702311..216705618)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217081612..217084915)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 5 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:217020960-217022159 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene DNA polymerase eta pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17093 Neighboring gene membrane associated ring-CH-type finger 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217147950-217148470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217148471-217148990 Neighboring gene uncharacterized LOC107985983 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:217180211-217181410 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:217183431-217184162 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:217184163-217184894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217205324-217206036 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217214111-217214808 Neighboring gene SMARCAL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217256655-217257184 Neighboring gene uncharacterized LOC107985984

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Anti-inflammatory and analgesic effects displayed by peptides derived from PKI55 protein, an endogenous protein kinase C inhibitor. Selvatici R, et al. Naunyn Schmiedebergs Arch Pharmacol, 2010 Sep. PMID 20644913
    2. Structural characterization of promoter sequences of the gene coding human PKI55 protein, a protein kinase C inhibitor. Borgatti M, et al. Biochimie, 2009 Apr. PMID 19095038
    3. Study of synthetic peptides derived from the PKI55 protein, a protein kinase C modulator, in human neutrophils stimulated by the methyl ester derivative of the hydrophobic N-formyl tripeptide for-Met-Leu-Phe-OH. Selvatici R, et al. FEBS J, 2008 Feb. PMID 18167144
    4. Effects of PKI55 protein, an endogenous protein kinase C modulator, on specific PKC isoforms activity and on human T cells proliferation. Selvatici R, et al. Arch Biochem Biophys, 2007 Jun 1. PMID 17467651
    5. Adaptative value of a PKC-PKI55 feedback loop of inhibition that prevents the kinase's deregulation. Selvatici R, et al. J Mol Evol, 2003 Aug. PMID 14562957

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA LINC01963 inhibits progression of pancreatic carcinoma by targeting miR-641/TMEFF2.
      Title: Long non-coding RNA LINC01963 inhibits progression of pancreatic carcinoma by targeting miR-641/TMEFF2.
    2. the interaction of GAGA transcription factors with Box 1 and Box 2 could regulate the transcription of the PKI55 gene and, consequently, the expression of PKC.
      Title: Structural characterization of promoter sequences of the gene coding human PKI55 protein, a protein kinase C inhibitor.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_037701.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL137534, CX783064, DA113272
      Related
      ENST00000562038.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      216216889..216220192
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      216702311..216705618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001199924.1: Suppressed sequence

      Description
      NM_001199924.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
    Nucleotide Protein
    Heading Accession and Version

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