Frk fyn-related kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Frkprovided by MGI
Official Full Name: fyn-related kinaseprovided by MGI
Primary source: MGI:MGI:103265
See related: Ensembl:ENSMUSG00000019779 AllianceGenome:MGI:103265
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BSK; GTK; RAK; BSK/IYK
Summary: Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in cell differentiation; cell surface receptor protein tyrosine kinase signaling pathway; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and sensory organ. Orthologous to human FRK (fyn related Src family tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in large intestine adult (RPKM 4.3), placenta adult (RPKM 3.4) and 17 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 18.85 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (34359396..34487530)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (34483400..34611232)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results show that FRK affects beta cell number during embryogenesis and early in life, but is probably redundant for beta cell number and function in adult animals under normal conditions.
Title: A role of FRK in regulation of embryonal pancreatic beta cell formation.
The tyrosine kinases Brk/PTK6/Sik, Srm, Frk/Rak/Gtk/Iyk/Bsk, and Src42A/Dsrc41 have a low degree of sequence homology to other known kinases. The exon structure of these kinases, called the Brk family, is highly conserved and distinct.
Title: Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases.
Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. Decreases in the circulating levels of T3 but not T4 are reminiscent of euthyroid sick syndrome, a stress-associated clinical condition
Title: Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak.
Experiments with Fyn-deficient mice indicate that Fyn genotype does not influence ethanol consumption, neither under basal conditions nor following a deprivation period or stress.
Title: Role of Fyn tyrosine kinase in ethanol consumption by mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Frk (e-PCR), detects polymorphism
- UniSTS:143142

PMC139782P1 (e-PCR)
- UniSTS:270894

C85044 (e-PCR)
- UniSTS:180024

Z48757 (e-PCR)
- UniSTS:163474

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase FRK

Names: B-cell src-homology tyrosine kinase; beta-cell Src-homology tyrosine kinase; intestine tyrosine kinase

NP_001153016.1

EC 2.7.10.2

NP_001345698.1

EC 2.7.10.2

NP_034367.2

EC 2.7.10.2

XP_006512597.1

EC 2.7.10.2

XP_006512599.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159544.1 → NP_001153016.1 tyrosine-protein kinase FRK

See identical proteins and their annotated locations for NP_001153016.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longest transcript. Variants 1-3 all encode the same protein.

Source sequence(s)

AK052614, AK164460, AK166379, BP761286, CN665865, L36132

Consensus CDS

CCDS23781.1

UniProtKB/Swiss-Prot

Q61364, Q61745, Q922K9

Related

ENSMUSP00000130289.2, ENSMUST00000170771.3

Conserved Domains (3) summary

cd10369
Location:119 → 214

SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)

cd11845
Location:54 → 111

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05068
Location:232 → 501

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
NM_001358769.1 → NP_001345698.1 tyrosine-protein kinase FRK

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.

Source sequence(s)

AC153960, AK052614, AK164460, BP761286

Consensus CDS

CCDS23781.1

UniProtKB/Swiss-Prot

Q61364, Q61745, Q922K9

Conserved Domains (3) summary

cd10369
Location:119 → 214

SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)

cd11845
Location:54 → 111

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05068
Location:232 → 501

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
NM_010237.3 → NP_034367.2 tyrosine-protein kinase FRK

See identical proteins and their annotated locations for NP_034367.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 all encode the same protein.

Source sequence(s)

AK028855, AK164460, AK166379, BP761286

Consensus CDS

CCDS23781.1

UniProtKB/Swiss-Prot

Q61364, Q61745, Q922K9

Related

ENSMUSP00000019913.8, ENSMUST00000019913.15

Conserved Domains (3) summary

cd10369
Location:119 → 214

SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)

cd11845
Location:54 → 111

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05068
Location:232 → 501

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

34359396..34487530

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006512534.5 → XP_006512597.1 tyrosine-protein kinase FRK isoform X1

See identical proteins and their annotated locations for XP_006512597.1

UniProtKB/Swiss-Prot

Q61364, Q61745, Q922K9

Conserved Domains (3) summary

cd10369
Location:119 → 214

SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)

cd11845
Location:54 → 111

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05068
Location:232 → 501

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases
XM_006512536.5 → XP_006512599.1 tyrosine-protein kinase FRK isoform X1

See identical proteins and their annotated locations for XP_006512599.1

UniProtKB/Swiss-Prot

Q61364, Q61745, Q922K9

Conserved Domains (3) summary

cd10369
Location:119 → 214

SH2_Src_Frk; Src homology 2 (SH2) domain found in the Fyn-related kinase (Frk)

cd11845
Location:54 → 111

SH3_Src_like; Src homology 3 domain of Src kinase-like Protein Tyrosine Kinases

cd05068
Location:232 → 501

PTKc_Frk_like; Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases