Pwwp2b PWWP domain containing 2B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pwwp2bprovided by MGI
Official Full Name: PWWP domain containing 2Bprovided by MGI
Primary source: MGI:MGI:2142008
See related: Ensembl:ENSMUSG00000060260 AllianceGenome:MGI:2142008
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pwwp2; D7Ertd517e; D930023J19Rik
Summary: Predicted to enable NuRD complex binding activity. Involved in chromatin remodeling; positive regulation of transcription elongation by RNA polymerase II; and regulation of cold-induced thermogenesis. Located in nucleus. Orthologous to human PWWP2B (PWWP domain containing 2B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 153.8), lung adult (RPKM 14.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F4; 7 84.39 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (138828398..138847172)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (139248482..139267256)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study in HeLa, HEK293F, and mouse embryonic stem cells reveal that loss of PWWP2A/B leads to increases in histone acetylation predominantly at highly expressed genes, accompanied by decreases in Pol II elongation. Collectively, these findings suggest a role for PWWP2A/B in regulating transcription through the fine-tuning of histone acetylation dynamics at actively transcribed genes.
Title: A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

General gene information

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Markers

AU022154 (e-PCR)
- UniSTS:167526

AI594893 (e-PCR)
- UniSTS:165566

NoName (e-PCR)
- UniSTS:488181

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NuRD complex binding	ISO Inferred from Sequence Orthology more info
enables NuRD complex binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription elongation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: PWWP domain-containing protein 2B

Names: PWWP domain containing 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033206.2 → NP_001028378.1 PWWP domain-containing protein 2B isoform 2

See identical proteins and their annotated locations for NP_001028378.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the coding region, compared to variant 1,that results in a shorter protein (isoform 2) with a unique C-terminus, compared to isoform 1.

Source sequence(s)

AK158245, BC116669

Consensus CDS

CCDS40169.1

UniProtKB/TrEMBL

Q14AS8, Q3TYY8

Related

ENSMUSP00000091529.4, ENSMUST00000093993.5

Conserved Domains (1) summary

pfam10243
Location:189 → 344

MIP-T3; Microtubule-binding protein MIP-T3
NM_001098636.1 → NP_001092106.1 PWWP domain-containing protein 2B isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK158245, AK213732, BC116669

Consensus CDS

CCDS52427.1

UniProtKB/Swiss-Prot

E9Q9M8

UniProtKB/TrEMBL

Q14AS8

Related

ENSMUSP00000130888.2, ENSMUST00000172136.9

Conserved Domains (1) summary

cd05835
Location:498 → 583

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

138828398..138847172

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030241947.1 → XP_030097807.1 PWWP domain-containing protein 2B isoform X1

UniProtKB/TrEMBL

Q14AS8

Conserved Domains (1) summary

cd05835
Location:421 → 506

Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...