Akap13 A kinase anchor protein 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akap13provided by MGI
Official Full Name: A kinase anchor protein 13provided by MGI
Primary source: MGI:MGI:2676556
See related: Ensembl:ENSMUSG00000066406 AllianceGenome:MGI:2676556
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BRX; LBC; Ht31; AKAP-13; AKAP-Lbc; PROTO-LB; PROTO-LBC; 1700026G02Rik; 5730522G15Rik; 5830460E08Rik
Summary: Predicted to enable several functions, including MAP-kinase scaffold activity; guanyl-nucleotide exchange factor activity; and small GTPase binding activity. Involved in bone development; cardiac muscle cell differentiation; and regulation of sarcomere organization. Acts upstream of or within regulation of glucocorticoid mediated signaling pathway. Colocalizes with actin filament. Is expressed in 1st branchial arch; cardiac muscle tissue; future forebrain; heart; and limb. Orthologous to human AKAP13 (A-kinase anchoring protein 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 15.7), lung adult (RPKM 14.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D1; 7 43.76 cM

Exon count:: 42

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (75105271..75404357)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (75455526..75754609)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Akap13 haploinsufficiency led to sex-dependent, compulsive-like behavioral changes in a murine model. Interestingly, Akap13 haploinsufficiency also led to a sex-dependent increase in body weight.
Title: Mice deficient in AKAP13 (BRX) develop compulsive-like behavior and increased body weight.
These findings suggest that Akap13 haploinsufficient mice have a deficiency in early osteogenesis with a corresponding reduction in osteoblast number, but no impairment of mature osteoblast activity.
Title: Mice Deficient in AKAP13 (BRX) Are Osteoporotic and Have Impaired Osteogenesis.
Our results show that AKAP13-PKD1 signaling is critical for transcriptional regulation of key contractile, cell death, and metabolic pathways during the development of compensatory hypertrophy in vivo.
Title: Genome-Wide Gene Expression Analysis Shows AKAP13-Mediated PKD1 Signaling Regulates the Transcriptional Response to Cardiac Hypertrophy.
The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
Title: The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy.
AKAP-Lbc assembles a signaling complex composed of the kinases PKN, MLTK, MKK3, and p38 alpha that mediates the activation of p38 in cardiomyocytes in response to stress signals.
Title: A-kinase anchoring protein Lbc coordinates a p38 activating signaling complex controlling compensatory cardiac hypertrophy.
Cardiomyocytes of Akap13-null mice had deficient sarcomere formation, and developing hearts were thin-walled and mice died at embryonic day 10.5-11.0.
Title: The Rho guanine nucleotide exchange factor AKAP13 (BRX) is essential for cardiac development in mice.
AKAP13 plays a role in TLR2-mediated NF-kappaB activation; GEF-containing scaffold proteins may confer specificity to innate immune responses downstream of TLRs
Title: AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Gene trapped (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW125671 (e-PCR)
- UniSTS:208144

MHAa78a8.seq (e-PCR)
- UniSTS:208145

D1Rat183 (e-PCR)
- UniSTS:118545

NoName (e-PCR)
- UniSTS:224990

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables MAP-kinase scaffold activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP-kinase scaffold activity	ISO Inferred from Sequence Orthology more info
enables MAP-kinase scaffold activity	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in adrenergic receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adrenergic receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in bone development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiac muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell growth involved in cardiac muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear export	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of glucocorticoid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with actin filament	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
colocalizes_with cortical actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: A-kinase anchor protein 13

Names: A kinase (PRKA) anchor protein 13; type II cAMP-dependent protein kinase anchoring protein Ht31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029332.1 → NP_083608.1 A-kinase anchor protein 13

Status: VALIDATED

Source sequence(s)

AC113019, AC158749

Consensus CDS

CCDS52276.1

UniProtKB/Swiss-Prot

E9Q394, Q3UEI5

Related

ENSMUSP00000129784.2, ENSMUST00000166315.7

Conserved Domains (6) summary

cd00160
Location:1958 → 2152

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

cd13392
Location:2195 → 2297

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

pfam00169
Location:2195 → 2295

PH; PH domain

pfam02050
Location:2535 → 2645

FliJ; Flagellar FliJ protein

cl00040
Location:1755 → 1801

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cl02529
Location:165 → 219

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

75105271..75404357

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036153520.1 → XP_036009413.1 A-kinase anchor protein 13 isoform X1

Conserved Domains (5) summary

cd00160
Location:1999 → 2193

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2519 → 2674

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2236 → 2338

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1792 → 1848

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:1150 → 1298

opacity_OapA; opacity-associated protein OapA
XM_036153522.1 → XP_036009415.1 A-kinase anchor protein 13 isoform X3

Conserved Domains (6) summary

PRK12704
Location:2616 → 2686

PRK12704; phosphodiesterase; Provisional

cd00160
Location:1999 → 2193

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2532 → 2673

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2236 → 2338

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1792 → 1848

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:1150 → 1298

opacity_OapA; opacity-associated protein OapA
XM_036153521.1 → XP_036009414.1 A-kinase anchor protein 13 isoform X2

Conserved Domains (5) summary

cd00160
Location:1998 → 2192

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2518 → 2673

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2235 → 2337

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1792 → 1848

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:1150 → 1298

opacity_OapA; opacity-associated protein OapA
XM_036153523.1 → XP_036009416.1 A-kinase anchor protein 13 isoform X4

Conserved Domains (5) summary

cd00160
Location:1997 → 2191

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2517 → 2672

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2234 → 2336

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1792 → 1848

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:1150 → 1298

opacity_OapA; opacity-associated protein OapA
XM_036153525.1 → XP_036009418.1 A-kinase anchor protein 13 isoform X6

Conserved Domains (6) summary

PRK12704
Location:2595 → 2665

PRK12704; phosphodiesterase; Provisional

cd00160
Location:1977 → 2171

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2497 → 2652

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2214 → 2316

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1770 → 1826

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:1150 → 1298

opacity_OapA; opacity-associated protein OapA
XM_036153526.1 → XP_036009419.1 A-kinase anchor protein 13 isoform X8

Conserved Domains (6) summary

PRK12704
Location:2593 → 2663

PRK12704; phosphodiesterase; Provisional

cd00160
Location:1975 → 2169

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2495 → 2650

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2212 → 2314

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1770 → 1826

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:1150 → 1298

opacity_OapA; opacity-associated protein OapA
XM_036153524.1 → XP_036009417.1 A-kinase anchor protein 13 isoform X5

Conserved Domains (5) summary

cd00160
Location:1981 → 2175

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2501 → 2656

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2218 → 2320

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1774 → 1830

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:1150 → 1298

opacity_OapA; opacity-associated protein OapA
XM_036153527.1 → XP_036009420.1 A-kinase anchor protein 13 isoform X9

Conserved Domains (6) summary

PRK12704
Location:2577 → 2647

PRK12704; phosphodiesterase; Provisional

cd00160
Location:1959 → 2153

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2479 → 2634

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2196 → 2298

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1752 → 1808

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:1150 → 1298

opacity_OapA; opacity-associated protein OapA
XM_036153528.1 → XP_036009421.1 A-kinase anchor protein 13 isoform X11

Conserved Domains (6) summary

PRK12704
Location:2575 → 2645

PRK12704; phosphodiesterase; Provisional

cd00160
Location:1957 → 2151

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2477 → 2632

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2194 → 2296

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1752 → 1808

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:1150 → 1298

opacity_OapA; opacity-associated protein OapA
XM_006541256.4 → XP_006541319.1 A-kinase anchor protein 13 isoform X7

UniProtKB/TrEMBL

A0A140LJJ5

Related

ENSMUSP00000147237.2, ENSMUST00000207750.2

Conserved Domains (5) summary

cd00160
Location:1976 → 2170

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2553 → 2676

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR03835
Location:450 → 835

termin_org_DnaJ; terminal organelle assembly protein TopJ

cd13392
Location:2213 → 2315

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cl00040
Location:1773 → 1819

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006541254.5 → XP_006541317.1 A-kinase anchor protein 13 isoform X12

Conserved Domains (5) summary

cd00160
Location:1954 → 2148

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2531 → 2654

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR03835
Location:450 → 835

termin_org_DnaJ; terminal organelle assembly protein TopJ

cd13392
Location:2191 → 2293

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cl00040
Location:1751 → 1797

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006541253.5 → XP_006541316.1 A-kinase anchor protein 13 isoform X10

Conserved Domains (5) summary

cd00160
Location:1958 → 2152

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2535 → 2658

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR03835
Location:450 → 835

termin_org_DnaJ; terminal organelle assembly protein TopJ

cd13392
Location:2195 → 2297

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cl00040
Location:1755 → 1801

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006541255.5 → XP_006541318.1 A-kinase anchor protein 13 isoform X13

UniProtKB/Swiss-Prot

E9Q394

Conserved Domains (5) summary

cd00160
Location:1936 → 2130

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2513 → 2636

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR03835
Location:450 → 835

termin_org_DnaJ; terminal organelle assembly protein TopJ

cd13392
Location:2173 → 2275

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cl00040
Location:1733 → 1779

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_030243062.2 → XP_030098922.1 A-kinase anchor protein 13 isoform X14

Conserved Domains (5) summary

cd00160
Location:1935 → 2129

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2512 → 2635

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

TIGR03835
Location:450 → 835

termin_org_DnaJ; terminal organelle assembly protein TopJ

cd13392
Location:2172 → 2274

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cl00040
Location:1733 → 1779

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_036153529.1 → XP_036009422.1 A-kinase anchor protein 13 isoform X15

Conserved Domains (6) summary

PRK12704
Location:2409 → 2479

PRK12704; phosphodiesterase; Provisional

cd00160
Location:1791 → 1985

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:2311 → 2466

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:2028 → 2130

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:1584 → 1640

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins

NF033909
Location:942 → 1090

opacity_OapA; opacity-associated protein OapA
XM_036153530.1 → XP_036009423.1 A-kinase anchor protein 13 isoform X16

Conserved Domains (5) summary

PRK12704
Location:1310 → 1380

PRK12704; phosphodiesterase; Provisional

cd00160
Location:692 → 886

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:1212 → 1367

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:929 → 1031

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:485 → 541

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_006541258.5 → XP_006541321.1 A-kinase anchor protein 13 isoform X17

Conserved Domains (4) summary

cd00160
Location:669 → 863

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:1246 → 1369

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:906 → 1008

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cl00040
Location:466 → 512

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_036153531.1 → XP_036009424.1 A-kinase anchor protein 13 isoform X18

Conserved Domains (5) summary

PRK12704
Location:1285 → 1355

PRK12704; phosphodiesterase; Provisional

cd00160
Location:667 → 861

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:1187 → 1342

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:904 → 1006

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:462 → 518

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_030243065.2 → XP_030098925.1 A-kinase anchor protein 13 isoform X21

Conserved Domains (4) summary

cd00160
Location:629 → 823

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:1206 → 1329

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:866 → 968

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cl00040
Location:426 → 472

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_006541259.5 → XP_006541322.1 A-kinase anchor protein 13 isoform X19

Conserved Domains (4) summary

cd00160
Location:654 → 848

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:1231 → 1354

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:891 → 993

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cl00040
Location:451 → 497

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_036153532.1 → XP_036009425.1 A-kinase anchor protein 13 isoform X20

Conserved Domains (5) summary

PRK12704
Location:1254 → 1324

PRK12704; phosphodiesterase; Provisional

cd00160
Location:636 → 830

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:1156 → 1311

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:873 → 975

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:429 → 485

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins
XM_006541260.5 → XP_006541323.1 A-kinase anchor protein 13 isoform X22

Conserved Domains (4) summary

cd00160
Location:614 → 808

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:1191 → 1314

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:851 → 953

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cl00040
Location:411 → 457

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
XM_036153533.1 → XP_036009426.1 A-kinase anchor protein 13 isoform X23

Conserved Domains (5) summary

PRK12704
Location:1231 → 1301

PRK12704; phosphodiesterase; Provisional

cd00160
Location:613 → 807

RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

TIGR02168
Location:1133 → 1288

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd13392
Location:850 → 952

PH_AKAP13; A-kinase anchoring protein 13 Pleckstrin homology (PH) domain

cd20878
Location:407 → 463

C1_AKAP13; protein kinase C conserved region 1 (C1 domain) found in A-kinase anchor protein 13 (AKAP-13) and similar proteins