Hk1 hexokinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hk1provided by RGD
Official Full Name: hexokinase 1provided by RGD
Primary source: RGD:2796
See related: EnsemblRapid:ENSRNOG00000046891 AllianceGenome:RGD:2796
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: HKI; HEXOKIN
Summary: Enables several functions, including ATP binding activity; D-glucose binding activity; and hexokinase activity. Involved in several processes, including phosphorylation; response to ischemia; and response to ketamine. Located in caveola and mitochondrion. Part of protein-containing complex. Used to study obesity and urinary bladder cancer. Biomarker of colorectal cancer and pulmonary hypertension. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 4G; anemia (multiple); hematologic cancer (multiple); obesity; and retinitis pigmentosa. Orthologous to human HK1 (hexokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Testes (RPKM 630.4), Brain (RPKM 381.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20q11

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (30773222..30874814, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (30230488..30332099, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (31911460..31979780, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The HDAC Inhibitor Butyrate Impairs beta Cell Function and Activates the Disallowed Gene Hexokinase I.
Title: The HDAC Inhibitor Butyrate Impairs β Cell Function and Activates the Disallowed Gene Hexokinase I.
Mitochondrial bound hexokinase type I in normal and streptozotocin diabetic rat retina.
Title: Mitochondrial bound hexokinase type I in normal and streptozotocin diabetic rat retina.
alpha-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease.
Title: α-Synuclein fibrillation products trigger the release of hexokinase I from mitochondria: Protection by curcumin, and possible role in pathogenesis of Parkinson's disease.
specific roles of mitochondria bound-HK and SDH on the metabolism of each brain region, are reported.
Title: Mitochondria-Bound Hexokinase (mt-HK) Activity Differ in Cortical and Hypothalamic Synaptosomes: Differential Role of mt-HK in H(2)O(2) Depuration.
results suggest that phenylpyruvic acid is the cause of the reduction of glucose consumption by decreasing hexokinase activity. Therefore, production of ATP declines in brain cells.
Title: In-silico and in-vitro investigation on the phenylalanine metabolites' interactions with hexokinase of Rat's brain mitochondria.
There was an increase in hexokinase1 expression in right ventricle from pulmonary hypertension rats.
Title: Up-regulation of hexokinase1 in the right ventricle of monocrotaline induced pulmonary hypertension.
Data show statistically significant altered levels of Tpi1 and alteration of Hk1, Aldoc, Pgam1 and Gapdh with borderline significance in phencyclidine (PCP) rats compared to controls.
Title: The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia.
The results show that Hk1 and GLUT3 may play a role in the pathophysiology of ketamine-induced behavioral abnormalities.
Title: The expression of genes involved in glucose metabolism is affected by N-methyl-D-aspartate receptor antagonism: a putative link between metabolism and an animal model of psychosis.
The activities of HK in all subcellular fractions are enhanced in response to myocardial infarction
Title: Enhanced activity and subcellular redistribution of myocardial hexokinase after acute myocardial infarction.
Abeta-induced cellular redistribution and inactivation of neuronal HKI play important roles in oxidative stress and neurodegeneration in Alzheimer's disease
Title: Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D20Wox16 (e-PCR)
- UniSTS:239886

BI275478 (e-PCR)
- UniSTS:249637

RH138930 (e-PCR)
- UniSTS:221016

AI029744 (e-PCR)
- UniSTS:226211

RH138498 (e-PCR)
- UniSTS:220585

RH94785 (e-PCR)
- UniSTS:120032

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IC Inferred by Curator more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IC Inferred by Curator more info	PubMed
enables D-glucose binding	IDA Inferred from Direct Assay more info	PubMed
enables D-glucose binding	IEA Inferred from Electronic Annotation more info
enables fructokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fructokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glucokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables glucokinase activity	IEA Inferred from Electronic Annotation more info
enables glucokinase activity	ISO Inferred from Sequence Orthology more info
enables glucosamine kinase activity	IEA Inferred from Electronic Annotation more info
enables hexokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables hexokinase activity	IEA Inferred from Electronic Annotation more info
enables hexokinase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mannokinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mannokinase activity	IDA Inferred from Direct Assay more info	PubMed
enables mannokinase activity	ISO Inferred from Sequence Orthology more info
enables peptidoglycan binding	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in GDP-mannose biosynthetic process from glucose	IEA Inferred from Electronic Annotation more info
involved_in GDP-mannose biosynthetic process from glucose	ISO Inferred from Sequence Orthology more info
involved_in GDP-mannose biosynthetic process from mannose	IEA Inferred from Electronic Annotation more info
involved_in GDP-mannose biosynthetic process from mannose	ISO Inferred from Sequence Orthology more info
involved_in canonical glycolysis	IEA Inferred from Electronic Annotation more info
involved_in canonical glycolysis	ISO Inferred from Sequence Orthology more info
involved_in carbohydrate phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in carbohydrate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in fructose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose 6-phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose 6-phosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycolytic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in hexose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in intracellular glucose homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in maintenance of protein location in mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in mannose metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of anion channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in response to brassinosteroid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ketamine	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: hexokinase-1

Names: brain form hexokinase; hexokinase type I; hexokinase-A

NP_001380640.1

EC 2.7.1.1

NP_036866.2

EC 2.7.1.1

XP_038954360.2

EC 2.7.1.1

XP_038954362.1

EC 2.7.1.1

XP_038954363.1

EC 2.7.1.1

XP_063135041.1

EC 2.7.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393711.1 → NP_001380640.1 hexokinase-1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/TrEMBL

A0A8I5YBQ4

Related

ENSRNOP00000077266.1, ENSRNOT00000099595.2

Conserved Domains (3) summary

PTZ00107
Location:23 → 464

PTZ00107; hexokinase; Provisional

pfam00349
Location:473 → 671

Hexokinase_1

pfam03727
Location:677 → 911

Hexokinase_2
NM_012734.2 → NP_036866.2 hexokinase-1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000020

UniProtKB/Swiss-Prot

P05708

UniProtKB/TrEMBL

A0A8I6AJ28

Related

ENSRNOP00000098666.1, ENSRNOT00000168329.1

Conserved Domains (1) summary

PTZ00107
Location:462 → 907

PTZ00107; hexokinase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086038.1 Reference GRCr8

Range

30773222..30874814 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039098432.2 → XP_038954360.2 hexokinase-1 isoform X1

UniProtKB/TrEMBL

A0A8I6AUZ1

Related

ENSRNOP00000097442.1, ENSRNOT00000112632.2
XM_039098434.2 → XP_038954362.1 hexokinase-1 isoform X2

UniProtKB/TrEMBL

A0A8I5YBQ4

Conserved Domains (3) summary

PTZ00107
Location:23 → 464

PTZ00107; hexokinase; Provisional

pfam00349
Location:473 → 671

Hexokinase_1

pfam03727
Location:677 → 911

Hexokinase_2
XM_039098435.2 → XP_038954363.1 hexokinase-1 isoform X3

UniProtKB/Swiss-Prot

P05708

UniProtKB/TrEMBL

A0A8I6ARQ9

Related

ENSRNOP00000097394.1, ENSRNOT00000105408.2

Conserved Domains (3) summary

PTZ00107
Location:18 → 459

PTZ00107; hexokinase; Provisional

pfam00349
Location:468 → 666

Hexokinase_1

pfam03727
Location:672 → 906

Hexokinase_2
XM_063278971.1 → XP_063135041.1 hexokinase-1 isoform X4

Related

ENSRNOP00000093592.2, ENSRNOT00000115199.2