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    Srpx sushi-repeat-containing protein, X-linked [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64316, updated on 27-Nov-2024

    Summary

    Official Symbol
    Srpxprovided by RGD
    Official Full Name
    sushi-repeat-containing protein, X-linkedprovided by RGD
    Primary source
    RGD:70950
    See related
    EnsemblRapid:ENSRNOG00000088892 AllianceGenome:RGD:70950
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Drs
    Summary
    Predicted to be involved in phagolysosome assembly. Predicted to act upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; and response to endoplasmic reticulum stress. Predicted to be located in autophagosome and endoplasmic reticulum. Orthologous to human SRPX (sushi repeat containing protein X-linked). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Uterus (RPKM 89.9), Heart (RPKM 85.5) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Srpx in Genome Data Viewer
    Location:
    Xq12
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (15349498..15420389)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (12676984..12751296)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (14146618..14220756, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene retinitis pigmentosa GTPase regulator Neighboring gene transfer RNA alanine (anticodon CGC) 4 Neighboring gene synaptotagmin-like 5 Neighboring gene H2A.L variant histone 3 Neighboring gene H2A.P histone

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    sushi repeat-containing protein SRPX
    Names
    down-regulated by v-src
    sushi-repeat-containing protein, X chromosome

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022524.2NP_071969.1  sushi repeat-containing protein SRPX precursor

      See identical proteins and their annotated locations for NP_071969.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/Swiss-Prot
      Q5PPK5, Q63769
      UniProtKB/TrEMBL
      A6K020
      Related
      ENSRNOP00000048924.2, ENSRNOT00000045753.4
      Conserved Domains (3) summary
      cd00033
      Location:262317
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:175257
      HYR; HYR domain
      pfam13778
      Location:332449
      DUF4174; Domain of unknown function (DUF4174)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      15349498..15420389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256683.5XP_006256745.1  sushi repeat-containing protein SRPX isoform X1

      See identical proteins and their annotated locations for XP_006256745.1

      UniProtKB/TrEMBL
      A6K020
      Related
      ENSRNOP00000083955.1, ENSRNOT00000114608.2
      Conserved Domains (3) summary
      cd00033
      Location:242297
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      pfam02494
      Location:155237
      HYR; HYR domain
      pfam13778
      Location:312429
      DUF4174; Domain of unknown function (DUF4174)