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    Tyms thymidylate synthetase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29261, updated on 27-Nov-2024

    Summary

    Official Symbol
    Tymsprovided by RGD
    Official Full Name
    thymidylate synthetaseprovided by RGD
    Primary source
    RGD:3921
    See related
    EnsemblRapid:ENSRNOG00000037225 AllianceGenome:RGD:3921
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including folic acid binding activity; protein homodimerization activity; and thymidylate synthase activity. Involved in several processes, including dTMP biosynthetic process; intestinal epithelial cell maturation; and liver regeneration. Predicted to be located in mitochondrial inner membrane; mitochondrial matrix; and nucleus. Predicted to be active in cytosol and mitochondrion. Used to study urinary bladder cancer. Biomarker of colorectal adenocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; cerebral infarction; gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 144.9), Spleen (RPKM 129.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tyms in Genome Data Viewer
    Location:
    9q38
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (120760057..120776149, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (113313454..113329551, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (121918875..121931564, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene adenylate cyclase activating polypeptide 1 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene clusterin like 1 Neighboring gene zinc finger protein 729 like, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC156654

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables folic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heterocyclic compound binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables mRNA regulatory element binding translation repressor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sequence-specific mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables thymidylate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables thymidylate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables thymidylate synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables thymidylate synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cartilage development IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in dTMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dTMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dTMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dTMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dTTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in developmental growth IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in intestinal epithelial cell maturation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pyrimidine nucleobase metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to cytokine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to ethanol IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to folic acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to glucocorticoid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organophosphorus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to progesterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to toxic substance IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in tetrahydrofolate interconversion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in tetrahydrofolate metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in uracil metabolic process IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    thymidylate synthase
    Names
    TS
    TSase
    NP_062052.1
    XP_008765643.1
    XP_063122880.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019179.2NP_062052.1  thymidylate synthase

      See identical proteins and their annotated locations for NP_062052.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      A0JN23, P45352
      UniProtKB/TrEMBL
      A0A8I6G9V7, A6KFB7
      Related
      ENSRNOP00000084093.2, ENSRNOT00000093931.2
      Conserved Domains (1) summary
      PTZ00164
      Location:21307
      PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      120760057..120776149 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767421.3XP_008765643.1  thymidylate synthase isoform X1

      See identical proteins and their annotated locations for XP_008765643.1

      UniProtKB/TrEMBL
      A0A8I6G9V7
      Conserved Domains (1) summary
      pfam00303
      Location:14265
      Thymidylat_synt; Thymidylate synthase
    2. XM_063266810.1XP_063122880.1  thymidylate synthase isoform X2

    RNA

    1. XR_005488858.2 RNA Sequence