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    Pcsk7 proprotein convertase subtilisin/kexin type 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29606, updated on 27-Nov-2024

    Summary

    Official Symbol
    Pcsk7provided by RGD
    Official Full Name
    proprotein convertase subtilisin/kexin type 7provided by RGD
    Primary source
    RGD:3275
    See related
    EnsemblRapid:ENSRNOG00000017478 AllianceGenome:RGD:3275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PC7
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in Golgi membrane and trans-Golgi network. Orthologous to human PCSK7 (proprotein convertase subtilisin/kexin type 7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 95.3), Kidney (RPKM 94.9) and 9 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pcsk7 in Genome Data Viewer
    Location:
    8q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (55098821..55121416)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (46202079..46224699)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (50200069..50222655)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 164 Neighboring gene beta-secretase 1 Neighboring gene ring finger protein 214 Neighboring gene transgelin Neighboring gene uncharacterized LOC120094332 Neighboring gene SID1 transmembrane family, member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within protein processing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    proprotein convertase subtilisin/kexin type 7
    Names
    prohormone convertase 7
    prohormone convertase PC7
    proprotein convertase 7
    proprotein convertase PC7
    rPC7
    subtilisin/kexin-like protease PC7
    NP_062119.1
    XP_038936896.1
    XP_063121098.1
    XP_063121099.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019246.2NP_062119.1  proprotein convertase subtilisin/kexin type 7 precursor

      See identical proteins and their annotated locations for NP_062119.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q62849
      UniProtKB/TrEMBL
      A6J459
      Related
      ENSRNOP00000023677.3, ENSRNOT00000023677.6
      Conserved Domains (4) summary
      cd04059
      Location:144439
      Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases
      pfam00082
      Location:195439
      Peptidase_S8; Subtilase family
      pfam01483
      Location:524611
      P_proprotein; Proprotein convertase P-domain
      pfam16470
      Location:52140
      S8_pro-domain; Peptidase S8 pro-domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      55098821..55121416
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265028.1XP_063121098.1  proprotein convertase subtilisin/kexin type 7 isoform X1

      UniProtKB/Swiss-Prot
      Q62849
      UniProtKB/TrEMBL
      A6J459
    2. XM_039080968.2XP_038936896.1  proprotein convertase subtilisin/kexin type 7 isoform X2

      Conserved Domains (2) summary
      cd04059
      Location:2224
      Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
      pfam01483
      Location:309396
      P_proprotein; Proprotein convertase P-domain
    3. XM_063265029.1XP_063121099.1  proprotein convertase subtilisin/kexin type 7 isoform X3

    RNA

    1. XR_005487748.2 RNA Sequence

    2. XR_005487749.2 RNA Sequence