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    Cox6a2 cytochrome c oxidase subunit 6A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25278, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cox6a2provided by RGD
    Official Full Name
    cytochrome c oxidase subunit 6A2provided by RGD
    Primary source
    RGD:2385
    See related
    EnsemblRapid:ENSRNOG00000019851 AllianceGenome:RGD:2385
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    COX6AH
    Summary
    Predicted to enable enzyme regulator activity. Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrion. Predicted to be part of respiratory chain complex IV. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 18. Orthologous to human COX6A2 (cytochrome c oxidase subunit 6A2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 9042.9) and Muscle (RPKM 5778.6) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cox6a2 in Genome Data Viewer
    Location:
    1q37
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192218970..192221188, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182788528..182790746, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199624037..199626255, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene integrin subunit alpha X Neighboring gene integrin subunit alpha D Neighboring gene RIKEN cDNA 9130023H24 gene like Neighboring gene armadillo repeat containing 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural organisation of the rat genes encoding liver- and heart-type of cytochrome c oxidase subunit VIa and a pseudogene related to the COXVIa-L cDNA. Mell OC, et al. Gene, 1994 Mar 25. PMID 8144025
    2. Characterization of two different genes (cDNA) for cytochrome c oxidase subunit VIa from heart and liver of the rat. Schlerf A, et al. EMBO J, 1988 Aug. PMID 2461293, Free PMC Article
    3. Tissue- and species-specific expression of cytochrome c oxidase isozymes in vertebrates. Kadenbach B, et al. Biochim Biophys Acta, 1990 Feb 2. PMID 2153407
    4. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    5. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytochrome-c oxidase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oxidative phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of respiratory chain complex IV IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex IV IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome c oxidase subunit 6A2, mitochondrial
    Names
    COXVIAH
    cytochrome c oxidase polypeptide VIa-heart
    cytochrome c oxidase subunit VIa polypeptide 2 (heart)
    NP_036944.2
    XP_006230280.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012812.3 → NP_036944.2  cytochrome c oxidase subunit 6A2, mitochondrial precursor

      See identical proteins and their annotated locations for NP_036944.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer transcript.
      Source sequence(s)
      BQ782365, FM058713
      UniProtKB/Swiss-Prot
      P10817
      UniProtKB/TrEMBL
      A6I9Y9, G3V8M4
      Related
      ENSRNOP00000026908.2, ENSRNOT00000026908.6
      Conserved Domains (1) summary
      cd00925
      Location:13 → 95
      Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

    RNA

    1. NR_037674.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction in a 5' exon, compared to variant 1, which results in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BQ782365, FM058713, FM121690

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      192218970..192221188 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230218.1 → XP_006230280.1  cytochrome c oxidase subunit 6A2, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006230280.1

      UniProtKB/Swiss-Prot
      P10817
      UniProtKB/TrEMBL
      A6I9Y9, G3V8M4
      Conserved Domains (1) summary
      cd00925
      Location:13 → 95
      Cyt_c_Oxidase_VIa; Cytochrome c oxidase subunit VIa. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10817.3 GenPept UniProtKB/Swiss-Prot:P10817

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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