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    Akr7a3 aldo-keto reductase family 7 member A3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 26760, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Akr7a3provided by RGD
    Official Full Name
    aldo-keto reductase family 7 member A3provided by RGD
    Primary source
    RGD:628635
    See related
    EnsemblRapid:ENSRNOG00000017899 AllianceGenome:RGD:628635
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Afar; Akr7a1
    Summary
    Enables aldo-keto reductase (NADPH) activity. Involved in aflatoxin catabolic process. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in cytoplasm. Orthologous to several human genes including AKR7A3 (aldo-keto reductase family 7 member A3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 1889.4) and Liver (RPKM 308.9) See more
    Orthologs
    human all
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    Genomic context

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    See Akr7a3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (156876721..156884599)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (151590968..151601394)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (157801120..157813756)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S21, pseudogene 9 Neighboring gene uncharacterized LOC134487025 Neighboring gene MRT4 homolog, ribosome maturation factor Neighboring gene ER membrane protein complex subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter. Ellis EM, et al. Carcinogenesis, 2003 Apr. PMID 12727802
    2. The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily. Kozma E, et al. J Biol Chem, 2002 May 3. PMID 11839745
    3. Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin. Hayes JD, et al. Cancer Res, 1993 Sep 1. PMID 8395332
    4. An ethoxyquin-inducible aldehyde reductase from rat liver that metabolizes aflatoxin B1 defines a subfamily of aldo-keto reductases. Ellis EM, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234296, Free PMC Article
    5. cDNA cloning, expression and activity of a second human aflatoxin B1-metabolizing member of the aldo-keto reductase superfamily, AKR7A3. Knight LP, et al. Carcinogenesis, 1999 Jul. PMID 10383892

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrate that Akr7a3 mRNA and protein levels are consistently co-expressed along with Akr1b10, in both experimental rat liver carcinogenesis and some human hepatocellular carcinoma samples.
      Title: Aldo-Keto Reductases as Early Biomarkers of Hepatocellular Carcinoma: A Comparison Between Animal Models and Human HCC.
    2. structure and chromosomal localization and idetification of antioxidant response elements in the gene promoter
      Title: Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter.
    3. A dimeric member of the aldo-keto reductase superfamily; structure resolved to 1.38A resolution (AKR7A1, aflatoxin dialdehyde reductase AKR7A1)
      Title: The crystal structure of rat liver AKR7A1. A dimeric member of the aldo-keto reductase superfamily.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aldo-keto reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldo-keto reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aflatoxin catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in aflatoxin metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aflatoxin B1 aldehyde reductase member 3
    Names
    AFB1-AR
    aflatoxin B1 aldehyde reductase member 1
    aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
    rAFAR1
    NP_037347.1
    XP_038965273.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013215.2 → NP_037347.1  aflatoxin B1 aldehyde reductase member 3

      See identical proteins and their annotated locations for NP_037347.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P38918, Q5EBB7, Q68FZ3, Q9QX16
      UniProtKB/TrEMBL
      A0A8L2QCW7, A6ITL5
      Related
      ENSRNOP00000024160.3, ENSRNOT00000024160.4
      Conserved Domains (1) summary
      cd19075
      Location:6 → 315
      AKR_AKR7A1-5; AKR7A family of aldo-keto reductase (AKR)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      156876721..156884599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109345.2 → XP_038965273.1  aflatoxin B1 aldehyde reductase member 3 isoform X1

      Conserved Domains (1) summary
      cd19075
      Location:2 → 239
      AKR_AKR7A1-5; AKR7A family of aldo-keto reductase (AKR)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38918.2 GenPept UniProtKB/Swiss-Prot:P38918

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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