Gadd45b growth arrest and DNA-damage-inducible, beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gadd45bprovided by RGD
Official Full Name: growth arrest and DNA-damage-inducible, betaprovided by RGD
Primary source: RGD:1309080
See related: EnsemblRapid:ENSRNOG00000019822 AllianceGenome:RGD:1309080
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in positive regulation of MAPK cascade; positive regulation of apoptotic process; and regulation of cell cycle. Predicted to act upstream of or within negative regulation of protein kinase activity and positive regulation of MAPK cascade. Predicted to be active in cytoplasm and nucleus. Orthologous to human GADD45B (growth arrest and DNA damage inducible beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 121.0), Spleen (RPKM 63.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9428689..9430991, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (8778004..8780306, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11646283..11648338, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of Gadd45beta alleviates osteoarthritis by repressing lipopolysaccharide-induced fibroblast-like synoviocyte inflammation, proliferation and migration.
Title: Downregulation of Gadd45β alleviates osteoarthritis by repressing lipopolysaccharide-induced fibroblast-like synoviocyte inflammation, proliferation and migration.
Gadd45b is a novel mediator of depression-like behaviors and neuroinflammation after cerebral ischemia.
Title: Gadd45b is a novel mediator of depression-like behaviors and neuroinflammation after cerebral ischemia.
Gadd45b mediates environmental enrichment-induced neurogenesis in the SVZ of rats following ischemia stroke via BDNF.
Title: Gadd45b mediates environmental enrichment-induced neurogenesis in the SVZ of rats following ischemia stroke via BDNF.
The results suggest that the ALK5 signaling pathway plays a critical role in mediating neural plasticity and neurological function recovery via Gadd45b after cerebral ischemia.
Title: ALK5 signaling pathway mediates neurogenesis and functional recovery after cerebral ischemia/reperfusion in rats via Gadd45b.
exposure to an acute stress upregulates Bdnf expression in the prefrontal cortex which is selectively impaired in prenatal stress female rats, an effect that was associated with changes in the modulation of the DNA demethylase Gadd45beta.
Title: Sex-Specific Effects of Prenatal Stress on Bdnf Expression in Response to an Acute Challenge in Rats: a Role for Gadd45β.
Report of sex differences in the expression of growth arrest and DNA damage inducible factor beta (Gadd45b), but not family members alpha (a) or gamma (g), in the neonatal and juvenile rodent amygdala
Title: Sex differences in Gadd45b expression and methylation in the developing rodent amygdala.
Data show that nonylphenol (NP) increased serum alkaline phosphatase, lead to liver damage and can increase the expression of heme oxygenase-1 (HO1) and growth arrest and DNA-damage-inducible 45 beta protein (Gadd45b) genes and may modify the toxic effects on liver through induction of oxidative stress.
Title: Nonylphenol induces liver toxicity and oxidative stress in rat.
The data suggested that Gadd45b inhibited autophagy and apoptosis under oxygen-glucose deprivation/reperfusion injury. Gadd45b may be a common regulatory protein to control autophagy and apoptosis.
Title: Gadd45b prevents autophagy and apoptosis against rat cerebral neuron oxygen-glucose deprivation/reperfusion injury.
Gadd45b knockdown decreased BDNF expression and the p-CREB pathway after brain neuron oxygen-glucose deprivation and reperfusion. It increased methylation of the 4th CpG island (105 bp apart from BDNF IXa).
Title: Huwe1 interacts with Gadd45b under oxygen-glucose deprivation and reperfusion injury in primary Rat cortical neuronal cells.
RNAi knockdown of Gadd45b significantly inhibits axonal plasticity in the rat brain and limits functional recovery after middle cerebral artery occlusion. It also decreased expression of both the BDNF and pCREB pathways and promoted ROCK expression.
Title: Gadd45b Mediates Axonal Plasticity and Subsequent Functional Recovery After Experimental Stroke in Rats.

Submit: New GeneRIF Correction See all GeneRIFs (16)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:546779

Gadd45b (e-PCR), detects polymorphism
- UniSTS:546779

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell cycle	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: growth arrest and DNA damage-inducible protein GADD45 beta

Names: growth arrest and DNA-damage-inducible 45 beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008321.1 → NP_001008322.1 growth arrest and DNA damage-inducible protein GADD45 beta

See identical proteins and their annotated locations for NP_001008322.1

Status: PROVISIONAL

Source sequence(s)

BC085337

UniProtKB/TrEMBL

F7FLQ8, Q5U3Z2

Related

ENSRNOP00000026871.2, ENSRNOT00000026871.6

Conserved Domains (1) summary

pfam01248
Location:21 → 120

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

9428689..9430991 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240888.5 → XP_006240950.1 growth arrest and DNA damage-inducible protein GADD45 beta isoform X1

Conserved Domains (1) summary

pfam01248
Location:21 → 120

Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family