Fbxo45 F-box protein 45 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Fbxo45provided by RGD
Full Name: F-box protein 45provided by RGD
Primary source: RGD:1311861
See related: EnsemblRapid:ENSRNOG00000067589 AllianceGenome:RGD:1311861
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311861
Summary: Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including protein K48-linked ubiquitination; regulation of synaptic vesicle exocytosis; and synapse assembly involved in innervation. Predicted to act upstream of or within nervous system development. Predicted to be located in postsynaptic density. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in glutamatergic synapse; postsynaptic cytosol; and presynaptic cytosol. Orthologous to human FBXO45 (F-box protein 45). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 107.0), Muscle (RPKM 71.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (82056457..82072080)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (68551430..68567053)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (71795977..71811858)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin-like ligase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like ligase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in anterior commissure morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior commissure morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex radially oriented cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex radially oriented cell migration	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex tangential migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex tangential migration	ISO Inferred from Sequence Orthology more info
involved_in corticospinal tract morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within corticospinal tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within innervation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in synapse assembly involved in innervation	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly involved in innervation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synapse assembly involved in innervation	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
NOT part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in postsynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in presynaptic cytosol	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic cytosol	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-box/SPRY domain-containing protein 1

Names: F-box only protein 45

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001398607.1 → NP_001385536.1 F-box/SPRY domain-containing protein 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

A0A8I6AS59

Related

ENSRNOP00000097158.1, ENSRNOT00000113542.2

Conserved Domains (2) summary

cd12907
Location:115 → 289

SPRY_Fbox; SPRY domain in the F-box family Fbxo45

pfam12937
Location:41 → 86

F-box-like