Hook2 hook microtubule-tethering protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hook2provided by RGD
Official Full Name: hook microtubule-tethering protein 2provided by RGD
Primary source: RGD:1310171
See related: EnsemblRapid:ENSRNOG00000003682 AllianceGenome:RGD:1310171
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dynein light intermediate chain binding activity; identical protein binding activity; and microtubule binding activity. Predicted to be involved in several processes, including early endosome to late endosome transport; endosome to lysosome transport; and protein localization to perinuclear region of cytoplasm. Predicted to be located in cytosol and trans-Golgi network. Predicted to be part of FHF complex and HOPS complex. Predicted to be active in centrosome and cytoplasm. Orthologous to human HOOK2 (hook microtubule tethering protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Kidney (RPKM 131.8), Testes (RPKM 119.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q11

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (40056732..40075027, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (23151869..23170139, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (26106713..26119353)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cytoplasmic microtubule organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton-dependent intracellular transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome organization	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of FHF complex	ISO Inferred from Sequence Orthology more info
part_of HOPS complex	ISO Inferred from Sequence Orthology more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein Hook homolog 2

Names: hook homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100562.1 → NP_001094032.1 protein Hook homolog 2 isoform 2

Status: VALIDATED

Source sequence(s)

BC099235, BQ203898, CB548211, CB696289, CB785578

UniProtKB/TrEMBL

E9PTX3

Conserved Domains (2) summary

pfam05622
Location:8 → 706

HOOK; HOOK protein

pfam10267
Location:260 → 344

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
NM_001415053.1 → NP_001401982.1 protein Hook homolog 2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6IY41

Related

ENSRNOP00000033999.5, ENSRNOT00000035987.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

40056732..40075027 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097685.2 → XP_038953613.1 protein Hook homolog 2 isoform X3

UniProtKB/TrEMBL

E9PTX3

Conserved Domains (2) summary

pfam05622
Location:215 → 737

HOOK; HOOK protein

pfam19047
Location:52 → 193

HOOK_N; HOOK domain
XM_039097684.2 → XP_038953612.1 protein Hook homolog 2 isoform X2

UniProtKB/TrEMBL

E9PTX3

Related

ENSRNOP00000108421.1, ENSRNOT00000128519.1

Conserved Domains (2) summary

pfam05622
Location:215 → 738

HOOK; HOOK protein

pfam19047
Location:52 → 193

HOOK_N; HOOK domain
XM_063277971.1 → XP_063134041.1 protein Hook homolog 2 isoform X7
XM_039097683.2 → XP_038953611.1 protein Hook homolog 2 isoform X1

UniProtKB/TrEMBL

E9PTX3

Conserved Domains (2) summary

pfam05622
Location:179 → 768

HOOK; HOOK protein

pfam19047
Location:7 → 157

HOOK_N; HOOK domain
XM_006255258.5 → XP_006255320.1 protein Hook homolog 2 isoform X4

UniProtKB/TrEMBL

E9PTX3

Conserved Domains (2) summary

pfam05622
Location:8 → 703

HOOK; HOOK protein

pfam10267
Location:260 → 344

Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
XM_063277969.1 → XP_063134039.1 protein Hook homolog 2 isoform X5
XM_039097686.2 → XP_038953614.1 protein Hook homolog 2 isoform X8

UniProtKB/TrEMBL

Q4FZR1

Conserved Domains (2) summary

pfam05622
Location:110 → 632

HOOK; HOOK protein

pfam19047
Location:60 → 88

HOOK_N; HOOK domain
XM_063277972.1 → XP_063134042.1 protein Hook homolog 2 isoform X7
XM_063277970.1 → XP_063134040.1 protein Hook homolog 2 isoform X6

Related

ENSRNOP00000103421.1, ENSRNOT00000133566.1