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    Zfp574 zinc finger protein 574 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308434, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp574provided by RGD
    Official Full Name
    zinc finger protein 574provided by RGD
    Primary source
    RGD:1311420
    See related
    EnsemblRapid:ENSRNOG00000055761 AllianceGenome:RGD:1311420
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf574
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF574 (zinc finger protein 574). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 53.3), Kidney (RPKM 46.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp574 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (89798412..89805490)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (80667984..80678257)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (81952067..81957330)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ATPase Na+/K+ transporting subunit alpha 3 Neighboring gene glutamate ionotropic receptor kainate type subunit 5 Neighboring gene POU class 2 homeobox 2 Neighboring gene uncharacterized LOC103691054 Neighboring gene U6 spliceosomal RNA Neighboring gene death effector domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 574

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024258.1 → NP_001019429.1  zinc finger protein 574

      See identical proteins and their annotated locations for NP_001019429.1

      Status: PROVISIONAL

      Source sequence(s)
      BC094953
      UniProtKB/Swiss-Prot
      Q504L7
      UniProtKB/TrEMBL
      A6J938
      Related
      ENSRNOP00000082869.1, ENSRNOT00000116503.2
      Conserved Domains (4) summary
      cd11674
      Location:458 → 492
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:496 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:312 → 391
      zf-C2H2_8; C2H2-type zinc ribbon

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      89798412..89805490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111384.2 → XP_038967312.1  zinc finger protein 574 isoform X2

      UniProtKB/Swiss-Prot
      Q504L7
      UniProtKB/TrEMBL
      A6J938
      Related
      ENSRNOP00000083524.1, ENSRNOT00000096464.2
      Conserved Domains (4) summary
      cd11674
      Location:458 → 492
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:496 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:312 → 391
      zf-C2H2_8; C2H2-type zinc ribbon

    2. XM_008758930.3 → XP_008757152.1  zinc finger protein 574 isoform X2

      See identical proteins and their annotated locations for XP_008757152.1

      UniProtKB/Swiss-Prot
      Q504L7
      UniProtKB/TrEMBL
      A6J938
      Related
      ENSRNOP00000089598.1, ENSRNOT00000110459.2
      Conserved Domains (4) summary
      cd11674
      Location:458 → 492
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:496 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:312 → 391
      zf-C2H2_8; C2H2-type zinc ribbon

    3. XM_008758931.4 → XP_008757153.1  zinc finger protein 574 isoform X2

      See identical proteins and their annotated locations for XP_008757153.1

      UniProtKB/Swiss-Prot
      Q504L7
      UniProtKB/TrEMBL
      A6J938
      Conserved Domains (4) summary
      cd11674
      Location:458 → 492
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:496 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:312 → 391
      zf-C2H2_8; C2H2-type zinc ribbon

    4. XM_039111397.2 → XP_038967325.1  zinc finger protein 574 isoform X2

      UniProtKB/Swiss-Prot
      Q504L7
      UniProtKB/TrEMBL
      A6J938
      Conserved Domains (4) summary
      cd11674
      Location:458 → 492
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:496 → 850
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:498 → 518
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:312 → 391
      zf-C2H2_8; C2H2-type zinc ribbon

    5. XM_039111377.2 → XP_038967305.1  zinc finger protein 574 isoform X1

      Related
      ENSRNOP00000070796.2, ENSRNOT00000079847.3
      Conserved Domains (4) summary
      cd11674
      Location:469 → 503
      lambda-1; inner capsid protein lambda-1 or VP3
      COG5048
      Location:507 → 861
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:509 → 529
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam15909
      Location:323 → 402
      zf-C2H2_8; C2H2-type zinc ribbon
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q504L7.1 GenPept UniProtKB/Swiss-Prot:Q504L7

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