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    Cdk7 cyclin-dependent kinase 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171150, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cdk7provided by RGD
    Official Full Name
    cyclin-dependent kinase 7provided by RGD
    Primary source
    RGD:621124
    See related
    EnsemblRapid:ENSRNOG00000018510 AllianceGenome:RGD:621124
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CAK; P39 Mo15
    Summary
    Enables cyclin-dependent protein serine/threonine kinase activity. Involved in protein phosphorylation and transcription by RNA polymerase II. Part of transcription factor TFIIH holo complex. Orthologous to human CDK7 (cyclin dependent kinase 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 187.4), Adrenal (RPKM 173.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cdk7 in Genome Data Viewer
    Location:
    2q12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (33574623..33599485, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (31840558..31865422, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (30710642..30735522, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene RAD17 checkpoint clamp loader component Neighboring gene TATA-box binding protein associated factor 9 Neighboring gene adenylate kinase 6 Neighboring gene coiled-coil domain containing 125 Neighboring gene KtI12 chromatin associated, pseudogene 1 Neighboring gene alpha-ketoglutarate dehydrogenase subunit 4 Neighboring gene uncharacterized LOC134485587

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP-dependent activity, acting on DNA  
    enables ATP-dependent activity, acting on DNA  
    enables ATP-dependent activity, acting on DNA  
    enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity  
    enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity  
    enables RNA polymerase II CTD heptapeptide repeat S7 kinase activity  
    enables RNA polymerase II CTD heptapeptide repeat T4 kinase activity  
    enables RNA polymerase II CTD heptapeptide repeat Y1 kinase activity  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity  
    enables RNA polymerase II CTD heptapeptide repeat kinase activity  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables cyclin-dependent protein serine/threonine kinase activity PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables cyclin-dependent protein serine/threonine kinase activity  
    enables kinase activity  
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein-containing complex binding PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair  
    involved_in cell division  
    involved_in meiotic cell cycle  
    involved_in positive regulation of meiotic cell cycle process involved in oocyte maturation  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein phosphorylation PubMed 
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of G1/S transition of mitotic cell cycle  
    involved_in regulation of G1/S transition of mitotic cell cycle  
    involved_in regulation of cell cycle  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in transcription by RNA polymerase II PubMed 
    involved_in transcription initiation at RNA polymerase II promoter  
    involved_in transcription initiation at RNA polymerase II promoter  
    Items 1 - 20 of 28
    Component Evidence Code Pubs
    part_of CAK-ERCC2 complex  
    part_of CAK-ERCC2 complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    part_of cyclin-dependent protein kinase holoenzyme complex  
    part_of cyclin-dependent protein kinase holoenzyme complex PubMed 
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in fibrillar center  
    located_in fibrillar center  
    located_in germinal vesicle  
    located_in male germ cell nucleus  
    located_in male germ cell nucleus  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of transcription factor TFIIH core complex  
    part_of transcription factor TFIIH core complex  
    part_of transcription factor TFIIH holo complex PubMed 
    part_of transcription factor TFIIH holo complex  
    part_of transcription factor TFIIH holo complex  
    part_of transcription factor TFIIK complex  
    part_of transcription factor TFIIK complex  
    part_of transcription factor TFIIK complex  
    Items 1 - 20 of 28

    General protein information

    Preferred Names
    cyclin-dependent kinase 7
    Names
    39 protein kinase
    CDK-activating kinase 1
    TFIIH basal transcription factor complex kinase subunit
    cell division protein kinase 7
    cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)
    cyclin-dependent kinase 7 (homolog of Xenopus MO15 cdk-activating kinase)
    NP_001385585.1
    NP_001385586.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398656.1NP_001385585.1  cyclin-dependent kinase 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P51952
      Related
      ENSRNOP00000025026.8, ENSRNOT00000025026.10
      Conserved Domains (1) summary
      cd07841
      Location:11308
      STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7
    2. NM_001398657.1NP_001385586.1  cyclin-dependent kinase 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I5A2, F1LQC8
      Related
      ENSRNOP00000109241.1, ENSRNOT00000130894.1
      Conserved Domains (1) summary
      cd07841
      Location:11285
      STKc_CDK7; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      33574623..33599485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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