Mllt1 MLLT1, super elongation complex subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mllt1provided by RGD
Official Full Name: MLLT1, super elongation complex subunitprovided by RGD
Primary source: RGD:1588581
See related: EnsemblRapid:ENSRNOG00000048736 AllianceGenome:RGD:1588581
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of protein kinase activity. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 76.2), Lung (RPKM 73.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (1818204..1863091, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (1731077..1775985, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (10110389..10155305)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH124646 (e-PCR)
- UniSTS:161468

RH125746 (e-PCR)
- UniSTS:162501

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription elongation factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein ENL

Names: myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1; myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1; translocated to, 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106876.2 → NP_001100346.1 protein ENL

See identical proteins and their annotated locations for NP_001100346.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A6KQU1, M0R462

Related

ENSRNOP00000064141.3, ENSRNOT00000071211.3

Conserved Domains (3) summary

PRK10905
Location:218 → 351

PRK10905; cell division protein DamX; Validated

cd16906
Location:9 → 137

YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins

pfam17793
Location:483 → 543

AHD; ANC1 homology domain (AHD)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

1818204..1863091 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006244307.5 → XP_006244369.1 protein ENL isoform X1

UniProtKB/TrEMBL

A0A8I6AH62, M0R462

Related

ENSRNOP00000092239.1, ENSRNOT00000109046.2

Conserved Domains (3) summary

PRK10905
Location:176 → 309

PRK10905; cell division protein DamX; Validated

cd16906
Location:9 → 137

YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins

pfam17793
Location:441 → 501

AHD; ANC1 homology domain (AHD)
XM_039083136.2 → XP_038939064.1 protein ENL isoform X2

UniProtKB/TrEMBL

M0R462

Conserved Domains (3) summary

PLN03237
Location:125 → 381

PLN03237; DNA topoisomerase 2; Provisional

cl38902
Location:36 → 80

YEATS; YEATS domain family, chromatin reader proteins

pfam17793
Location:426 → 486

AHD; ANC1 homology domain (AHD)