Wdpcp WD repeat containing planar cell polarity effector [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wdpcpprovided by RGD
Official Full Name: WD repeat containing planar cell polarity effectorprovided by RGD
Primary source: RGD:1309501
See related: EnsemblRapid:ENSRNOG00000054331 AllianceGenome:RGD:1309501
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309501
Summary: Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in several processes, including cilium assembly; regulation of embryonic cell shape; and septin cytoskeleton organization. Predicted to act upstream of or within several processes, including embryonic digit morphogenesis; podocyte cell migration; and sensory organ morphogenesis. Predicted to be located in apical plasma membrane; axoneme; and cell cortex. Predicted to be active in axonemal basal plate. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome 15 and congenital heart defects, hamartomas of tongue, and polysyndactyly. Orthologous to human WDPCP (WD repeat containing planar cell polarity effector). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 53.9), Lung (RPKM 48.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q22

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (99847463..100178392)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (95645955..95977120)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (106393959..106759511)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D14Rat22 (e-PCR)
- UniSTS:118363

AU049356 (e-PCR)
- UniSTS:145803

AW532630 (e-PCR)
- UniSTS:260573

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in auditory receptor cell morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within auditory receptor cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in cilium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium organization	ISO Inferred from Sequence Orthology more info
involved_in circulatory system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circulatory system development	ISO Inferred from Sequence Orthology more info
involved_in digestive system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within digestive system development	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
involved_in podocyte cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within podocyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of establishment of cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of ruffle assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in respiratory system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within respiratory system development	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in septin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tongue morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tongue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in tongue morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in axonemal basal plate	IBA Inferred from Biological aspect of Ancestor more info
located_in axonemal basal plate	IEA Inferred from Electronic Annotation more info
located_in axonemal basal plate	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISS Inferred from Sequence or Structural Similarity more info
located_in cell cortex	ISS Inferred from Sequence or Structural Similarity more info
located_in cilium	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: WD repeat-containing and planar cell polarity effector protein fritz homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001127537.1 → NP_001121009.1 WD repeat-containing and planar cell polarity effector protein fritz homolog

See identical proteins and their annotated locations for NP_001121009.1

Status: PROVISIONAL

Source sequence(s)

BC161962

UniProtKB/Swiss-Prot

B1WC10

UniProtKB/TrEMBL

A0A0G2JXB0

Related

ENSRNOP00000070201.2, ENSRNOT00000092168.3

Conserved Domains (2) summary

pfam11768
Location:48 → 591

DUF3312; Protein of unknown function (DUF3312)

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

99847463..100178392

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092074.2 → XP_038948002.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X1

UniProtKB/TrEMBL

A0A0G2JXB0

Conserved Domains (2) summary

sd00039
Location:330 → 365

7WD40; WD40 repeat [structural motif]

pfam11768
Location:68 → 664

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_063273244.1 → XP_063129314.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X3
XM_039092078.2 → XP_038948006.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X4

UniProtKB/TrEMBL

A0A0G2JXB0, A0A8I5Y2A3

Related

ENSRNOP00000078004.2, ENSRNOT00000101695.2

Conserved Domains (2) summary

sd00039
Location:330 → 365

7WD40; WD40 repeat [structural motif]

pfam11768
Location:68 → 611

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_063273245.1 → XP_063129315.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X5
XM_063273247.1 → XP_063129317.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X8
XM_063273249.1 → XP_063129319.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X10

Related

ENSRNOP00000090509.2, ENSRNOT00000107912.2
XM_039092085.2 → XP_038948013.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X11

Conserved Domains (2) summary

sd00039
Location:330 → 365

7WD40; WD40 repeat [structural motif]

pfam11768
Location:68 → 544

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_063273246.1 → XP_063129316.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X7
XM_039092081.2 → XP_038948009.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X6

UniProtKB/TrEMBL

A0A0G2JXB0

Conserved Domains (2) summary

sd00039
Location:231 → 266

7WD40; WD40 repeat [structural motif]

pfam11768
Location:1 → 565

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_063273242.1 → XP_063129312.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2
XM_063273240.1 → XP_063129310.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2
XM_039092076.2 → XP_038948004.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

UniProtKB/TrEMBL

A0A0G2JXB0

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 644

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_063273241.1 → XP_063129311.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2
XM_039092075.2 → XP_038948003.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2

UniProtKB/TrEMBL

A0A0G2JXB0

Conserved Domains (2) summary

sd00039
Location:310 → 345

7WD40; WD40 repeat [structural motif]

pfam11768
Location:48 → 644

Frtz; WD repeat-containing and planar cell polarity effector protein Fritz
XM_063273250.1 → XP_063129320.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X12
XM_063273248.1 → XP_063129318.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X9
XM_063273243.1 → XP_063129313.1 WD repeat-containing and planar cell polarity effector protein fritz homolog isoform X2