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    Snx14 sorting nexin 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315871, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx14provided by RGD
    Official Full Name
    sorting nexin 14provided by RGD
    Primary source
    RGD:1310921
    See related
    EnsemblRapid:ENSRNOG00000011348 AllianceGenome:RGD:1310921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity. Predicted to be involved in autophagosome maturation and postsynaptic modulation of chemical synaptic transmission. Predicted to be located in cytosol; lysosome; and postsynapse. Predicted to be active in late endosome and synapse. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 20. Orthologous to human SNX14 (sorting nexin 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 206.1), Thymus (RPKM 155.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx14 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (98053769..98278287, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (89283673..89390597, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (96018943..96088405, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC108351758 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene ribosomal protein S15, pseudogene 11 Neighboring gene GABA type A receptor associated protein like 3 Neighboring gene myosin light polypeptide 6-like Neighboring gene 5' nucleotidase, ecto Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein Neighboring gene small nucleolar RNA SNORD50 Neighboring gene synaptotagmin binding, cytoplasmic RNA interacting protein, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Biallelic mutations in SNX14 cause a syndromic form of cerebellar atrophy and lysosome-autophagosome dysfunction. Akizu N, et al. Nat Genet, 2015 May. PMID 25848753, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic modulation of chemical synaptic transmission ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in late endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108174.2 → NP_001101644.2  sorting nexin-14 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6AQL5
      Related
      ENSRNOP00000096281.2, ENSRNOT00000097638.2
      Conserved Domains (3) summary
      cd06877
      Location:555 → 677
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:340 → 466
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      cl02564
      Location:132 → 303
      PXA; PXA domain

    2. NM_001393685.1 → NP_001380614.1  sorting nexin-14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZLX0
      Related
      ENSRNOP00000053662.5, ENSRNOT00000056818.5
      Conserved Domains (3) summary
      cd06877
      Location:564 → 686
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:340 → 466
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      cl02564
      Location:132 → 303
      PXA; PXA domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      98053769..98278287 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081534.2 → XP_038937462.1  sorting nexin-14 isoform X2

      UniProtKB/TrEMBL
      A0A8I6GJA7
      Conserved Domains (4) summary
      cd06877
      Location:591 → 713
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:367 → 493
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:157 → 326
      PXA; PXA domain
      pfam08628
      Location:834 → 938
      Nexin_C; Sorting nexin C terminal

    2. XM_063265564.1 → XP_063121634.1  sorting nexin-14 isoform X1

      UniProtKB/TrEMBL
      A0A8I5YBU7, A0A8I6AT69

    3. XM_063265566.1 → XP_063121636.1  sorting nexin-14 isoform X5

      UniProtKB/TrEMBL
      D3ZLX0

    4. XM_063265565.1 → XP_063121635.1  sorting nexin-14 isoform X4

      UniProtKB/TrEMBL
      D3ZLX0

    5. XM_039081536.2 → XP_038937464.1  sorting nexin-14 isoform X3

      UniProtKB/TrEMBL
      D3ZLX0
      Related
      ENSRNOP00000069246.2, ENSRNOT00000086161.3
      Conserved Domains (4) summary
      cd06877
      Location:582 → 704
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:367 → 493
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:157 → 326
      PXA; PXA domain
      pfam08628
      Location:825 → 929
      Nexin_C; Sorting nexin C terminal

    6. XM_039081537.2 → XP_038937465.1  sorting nexin-14 isoform X6

      UniProtKB/TrEMBL
      A0A8I6GJA7
      Conserved Domains (3) summary
      cd06877
      Location:591 → 713
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:367 → 493
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:157 → 326
      PXA; PXA domain

    RNA

    1. XR_010053970.1 RNA Sequence

    2. XR_010053971.1 RNA Sequence

    3. XR_005487837.2 RNA Sequence

    4. XR_010053969.1 RNA Sequence

    5. XR_010053967.1 RNA Sequence

    6. XR_010053968.1 RNA Sequence

    7. XR_005487839.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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