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    Csmd1 CUB and Sushi multiple domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 364634, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Csmd1provided by RGD
    Official Full Name
    CUB and Sushi multiple domains 1provided by RGD
    Primary source
    RGD:1305103
    See related
    EnsemblRapid:ENSRNOG00000030719 AllianceGenome:RGD:1305103
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mdcr1
    Summary
    Predicted to act upstream of or within several processes, including learning or memory; mammary gland branching involved in pregnancy; and reproductive structure development. Predicted to be located in membrane. Orthologous to human CSMD1 (CUB and Sushi multiple domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 90.9), Kidney (RPKM 11.6) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Csmd1 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    70
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (78920549..80520710)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (72218189..73818380)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (77152823..78850222)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482557 Neighboring gene uncharacterized LOC108348426 Neighboring gene uncharacterized LOC120097408 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene cyclin-dependent kinase 4 pseudogene Neighboring gene uncharacterized LOC134482524 Neighboring gene uncharacterized LOC102550761 Neighboring gene uncharacterized LOC134482558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Neuropsychological deficits in mice depleted of the schizophrenia susceptibility gene CSMD1. Steen VM, et al. PLoS One, 2013. PMID 24244513, Free PMC Article
    2. Epigenetic inactivation and aberrant transcription of CSMD1 in squamous cell carcinoma cell lines. Richter TM, et al. Cancer Cell Int, 2005 Sep 9. PMID 16153303, Free PMC Article
    3. CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues. Kraus DM, et al. J Immunol, 2006 Apr 1. PMID 16547280

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CSMD1 may be an important regulator of complement activation and inflammation in the developing central nervous system, and that it may also play a role in the context of growth cone function
      Title: CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues.
    2. the rat homolog of CSMD1 has complement inhibiting activity and is located in neuron growth cones.
      Title: CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within conditioned place preference ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within female gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within male gonad development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mammary gland branching involved in pregnancy ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within memory ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within oviduct epithelium development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within startle response ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CUB and sushi domain-containing protein 1
    Names
    multiple domain complement regulator 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037327.2 → NP_001032404.2  CUB and sushi domain-containing protein 1 precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      E9PT92, Q45NC2
      Related
      ENSRNOP00000054705.4, ENSRNOT00000057897.5
      Conserved Domains (4) summary
      cd00033
      Location:527 → 581
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:2087 → 2142
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:2619 → 2855
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:758 → 865
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      78920549..80520710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094737.2 → XP_038950665.1  CUB and sushi domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      Q45NC2
      Related
      ENSRNOP00000108941.1, ENSRNOT00000140156.1
      Conserved Domains (4) summary
      cd00033
      Location:527 → 581
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      smart00032
      Location:2087 → 2142
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      PHA02927
      Location:2619 → 2855
      PHA02927; secreted complement-binding protein; Provisional
      cd00041
      Location:758 → 865
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    Nucleotide Protein Strain
    Heading Accession and Version

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