Lats2 large tumor suppressor kinase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lats2provided by RGD
Official Full Name: large tumor suppressor kinase 2provided by RGD
Primary source: RGD:1305906
See related: EnsemblRapid:ENSRNOG00000056343 AllianceGenome:RGD:1305906
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; hippo signaling; and negative regulation of cyclin-dependent protein serine/threonine kinase activity. Predicted to act upstream of or within several processes, including inner cell mass cell differentiation; keratinocyte differentiation; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in centriolar satellite and cytosol. Predicted to be active in cytoplasm; nucleus; and spindle pole. Orthologous to human LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 210.8), Kidney (RPKM 137.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (35940632..35992225, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (31825068..31877193, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (37943609..37995175, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2.
Title: Upregulation of miR-215 attenuates propofol-induced apoptosis and oxidative stress in developing neurons by targeting LATS2.
Exosomal miR-135a derived from human amnion mesenchymal stem cells promotes cutaneous wound healing in rats and fibroblast migration by directly inhibiting LATS2 expression.
Title: Exosomal miR-135a derived from human amnion mesenchymal stem cells promotes cutaneous wound healing in rats and fibroblast migration by directly inhibiting LATS2 expression.
The overexpression of LATS2 induces mitochondrial stress by repressing protective mitophagy in a manner dependent on Prx3-Mfn2 pathways, thus reducing the survival of H9C2 cells.
Title: LATS2 promotes cardiomyocyte H9C2 cells apoptosis via the Prx3-Mfn2-mitophagy pathways.
MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog
Title: MicroRNA-31 regulated by the extracellular regulated kinase is involved in vascular smooth muscle cell growth via large tumor suppressor homolog 2.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139371 (e-PCR)
- UniSTS:221457

Lats2 (e-PCR), detects polymorphism
- UniSTS:495970

AI233961 (e-PCR)
- UniSTS:250351

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner cell mass cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner cell mass cellular morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of organ growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase LATS2

Names: large tumor suppressor 2; large tumor suppressor, homolog 2

NP_001100737.1

EC 2.7.11.1

XP_008768970.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107267.1 → NP_001100737.1 serine/threonine-protein kinase LATS2

See identical proteins and their annotated locations for NP_001100737.1

Status: PROVISIONAL

Source sequence(s)

CH474049

UniProtKB/TrEMBL

A0A0G2K4A8, A6KHC7

Related

ENSRNOP00000072969.1, ENSRNOT00000087978.3

Conserved Domains (3) summary

PHA03247
Location:143 → 490

PHA03247; large tegument protein UL36; Provisional

cd14398
Location:101 → 141

UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

cl21453
Location:624 → 1004

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

35940632..35992225 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008770748.4 → XP_008768970.1 serine/threonine-protein kinase LATS2 isoform X1

See identical proteins and their annotated locations for XP_008768970.1

UniProtKB/TrEMBL

A0A0G2K4A8, A6KHC7

Conserved Domains (3) summary

PHA03247
Location:143 → 490

PHA03247; large tegument protein UL36; Provisional

cd14398
Location:101 → 141

UBA_LATS2; UBA domain found in vertebrate serine/threonine-protein kinase LATS2

cl21453
Location:624 → 1004

PKc_like; Protein Kinases, catalytic domain