Mepce methylphosphate capping enzyme [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Mepceprovided by RGD
Full Name: methylphosphate capping enzymeprovided by RGD
Primary source: RGD:1560550
See related: EnsemblRapid:ENSRNOG00000001387 AllianceGenome:RGD:1560550
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 7SK snRNA binding activity and RNA 5'-gamma-phosphate methyltransferase activity. Predicted to be involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be located in nucleus. Predicted to be part of 7SK snRNP. Orthologous to human MEPCE (methylphosphate capping enzyme). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 87.9), Kidney (RPKM 77.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (24548596..24553315)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (18911796..18916515)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (21721246..21725965)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

C78815 (e-PCR)
- UniSTS:207898

WIAF-1510 (e-PCR)
- UniSTS:42291

RH142264 (e-PCR)
- UniSTS:231511

BE101310 (e-PCR)
- UniSTS:243544

RH125705 (e-PCR)
- UniSTS:142574

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 7SK snRNA binding	ISO Inferred from Sequence Orthology more info
enables O-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 5'-gamma-phosphate methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables S-adenosylmethionine-dependent methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables snRNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in RNA methylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to Cajal body	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of snRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in snRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in snRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA modification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of 7SK snRNP	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 7SK snRNA methylphosphate capping enzyme

Names: 7SK snRNA methylphosphate capping enzyme-like

NP_001094148.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100678.1 → NP_001094148.1 7SK snRNA methylphosphate capping enzyme

See identical proteins and their annotated locations for NP_001094148.1

Status: VALIDATED

Source sequence(s)

AA925609, BC088435, JAXUCZ010000012

UniProtKB/TrEMBL

A6IZZ6, G3V656

Related

ENSRNOP00000001871.5, ENSRNOT00000001871.7

Conserved Domains (2) summary

cd02440
Location:417 → 587

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

pfam06859
Location:546 → 654

Bin3; Bicoid-interacting protein 3 (Bin3)