Tgfbi transforming growth factor, beta induced [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgfbiprovided by RGD
Official Full Name: transforming growth factor, beta inducedprovided by RGD
Primary source: RGD:620017
See related: EnsemblRapid:ENSRNOG00000012216 AllianceGenome:RGD:620017
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BIGH3; Big-h3
Summary: Predicted to enable several functions, including collagen binding activity; extracellular matrix binding activity; and identical protein binding activity. Involved in chondrocyte differentiation. Located in basement membrane. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in corneal dystrophy (multiple). Orthologous to human TGFBI (transforming growth factor beta induced). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 673.6), Thymus (RPKM 329.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (7960885..7990234, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (7955603..7984903, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (8400123..8429338, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

betaig-h3 enhances chondrogenesis via promoting mesenchymal condensation in rat Achilles tendon heterotopic ossification model.
Title: βig-h3 enhances chondrogenesis via promoting mesenchymal condensation in rat Achilles tendon heterotopic ossification model.
Studies reveal that growth hormone (GH)increases TGFBI expression in a mouse and rat models of diabetic nephropathy (DN) which correlate with clinical results, and suggest that this mechanism can explain the podocytes depletion in DN.
Title: Growth Hormone Induces Transforming Growth Factor-Beta-Induced Protein in Podocytes: Implications for Podocyte Depletion and Proteinuria.
betaig-h3 expression and lysosomal activity a key factor in the induction of albuminuria and cardiovascular disease associated with hypertension
Title: Hypertension-mediated albuminuria is associated with reduced lysosomal activity in the kidney and the heart.
keratoepithelin may help to build up a bridge between collagen VI and yet unidentified muscle receptor
Title: First molecular characterization and immunolocalization of keratoepithelin in adult human skeletal muscle.
betaig-h3 may be important in development of diabetic nephropathy. Level of urinary betaig-h3 may be useful as early marker reflecting disease onset and progression.
Title: Expression of TGF-beta-induced matrix protein betaig-h3 is up-regulated in the diabetic rat kidney and human proximal tubular epithelial cells treated with high glucose.
These results suggest that mechanical strain negatively regulates the terminal differentiation of chondrocytes through the signal pathway of TGF-ss with the induction of RGD-CAP.
Title: Mechanical regulation of terminal chondrocyte differentiation via RGD-CAP/beta ig-h3 induced by TGF-beta.
Pravastatin significantly inhibited betaig-h3 mRNA production and gene expression within the tubulointerstitium of the CsA-treated kidneys.
Title: Inhibitory effect of pravastatin on transforming growth factor beta1-inducible gene h3 expression in a rat model of chronic cyclosporine nephropathy.
induced by TGF-beta in rat kidney
Title: Expression of transforming growth factor-beta-inducible gene-h3 in normal and cyclosporine-treated rat kidney.

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General gene information

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Markers

D17Wox2 (e-PCR)
- UniSTS:118061

D17Rat76 (e-PCR)
- UniSTS:118447

RH127317 (e-PCR)
- UniSTS:210627

RH129409 (e-PCR)
- UniSTS:212716

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables collagen binding	ISO Inferred from Sequence Orthology more info
enables extracellular matrix binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in chondrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transforming growth factor-beta-induced protein ig-h3

Names: transforming growth factor, beta induced, 68 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053802.1 → NP_446254.1 transforming growth factor-beta-induced protein ig-h3 precursor

Status: PROVISIONAL

Source sequence(s)

CA340798, CB578739, CD373288, CO383155, DY560207

UniProtKB/TrEMBL

D4A8G5

Related

ENSRNOP00000016389.8, ENSRNOT00000016390.9

Conserved Domains (1) summary

pfam02469
Location:514 → 634

Fasciclin; Fasciclin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

7960885..7990234 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095289.2 → XP_038951217.1 transforming growth factor-beta-induced protein ig-h3 isoform X1

UniProtKB/TrEMBL

D4A8G5

Related

ENSRNOP00000081900.2, ENSRNOT00000108364.2

Conserved Domains (1) summary

pfam02469
Location:514 → 634

Fasciclin; Fasciclin domain