Zw10 zw10 kinetochore protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zw10provided by RGD
Official Full Name: zw10 kinetochore proteinprovided by RGD
Primary source: RGD:1309197
See related: EnsemblRapid:ENSRNOG00000054479 AllianceGenome:RGD:1309197
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase chromosome alignment; and regulation of mitotic cell cycle phase transition. Predicted to be located in several cellular components, including kinetochore; lipid droplet; and spindle. Predicted to be part of Dsl1/NZR complex and RZZ complex. Orthologous to human ZW10 (zw10 kinetochore protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 112.1), Muscle (RPKM 84.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q23

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (58292959..58317881)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (49396541..49424743)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (53365881..53390742)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

targeting of ZW10 to the perinuclear Golgi region was found to depend on the perinuclear accumulation of dynactin
Title: Correlation of Golgi localization of ZW10 and centrosomal accumulation of dynactin.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in Golgi organization	ISO Inferred from Sequence Orthology more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
involved_in mitotic metaphase chromosome alignment	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in mitotic sister chromatid segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Dsl1/NZR complex	ISO Inferred from Sequence Orthology more info
part_of RZZ complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RZZ complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in kinetochore microtubule	ISO Inferred from Sequence Orthology more info
located_in kinetochore microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	ISO Inferred from Sequence Orthology more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: centromere/kinetochore protein zw10 homolog

Names: ZW10 homolog, centromere/kinetochore protein; ZW10, kinetochore associated, homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024801.2 → NP_001019972.1 centromere/kinetochore protein zw10 homolog isoform 1

See identical proteins and their annotated locations for NP_001019972.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q4V8C2

UniProtKB/TrEMBL

A6J4B1

Related

ENSRNOP00000071533.1, ENSRNOT00000080712.3

Conserved Domains (1) summary

pfam06248
Location:9 → 561

Zw10; Centromere/kinetochore Zw10
NM_001429477.1 → NP_001416406.1 centromere/kinetochore protein zw10 homolog isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

58292959..58317881

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265741.1 → XP_063121811.1 centromere/kinetochore protein zw10 homolog isoform X1
XM_039081724.2 → XP_038937652.2 centromere/kinetochore protein zw10 homolog isoform X2