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    Rdh14 retinol dehydrogenase 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500629, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rdh14provided by RGD
    Official Full Name
    retinol dehydrogenase 14provided by RGD
    Primary source
    RGD:1565196
    See related
    EnsemblRapid:ENSRNOG00000039551 AllianceGenome:RGD:1565196
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565196
    Summary
    Predicted to enable all-trans-retinol dehydrogenase (NADP+) activity. Predicted to act upstream of or within retinol metabolic process. Predicted to be located in cytosol; endoplasmic reticulum; and nucleoplasm. Orthologous to human RDH14 (retinol dehydrogenase 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 184.4), Heart (RPKM 121.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rdh14 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (38875693..38880836)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (33156569..33161712)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (36106926..36112069)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene U1 small nuclear ribonucleoprotein 70 kDa-like Neighboring gene large ribosomal subunit protein eL38-like Neighboring gene 5'-nucleotidase, cytosolic IB Neighboring gene uncharacterized LOC120103512 Neighboring gene uncharacterized LOC120103513

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. RDH13L, an enzyme responsible for the aldehyde-alcohol redox coupling reaction (AL-OL coupling reaction) to supply 11-cis retinal in the carp cone retinoid cycle. Sato S, et al. J Biol Chem, 2015 Jan 30. PMID 25533474, Free PMC Article
    2. Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues. Belyaeva OV, et al. FEBS Lett, 2002 Nov 20. PMID 12435598
    3. Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. Haeseleer F, et al. J Biol Chem, 2002 Nov 22. PMID 12226107, Free PMC Article
    4. Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation. Foster LJ, et al. Stem Cells, 2005 Oct. PMID 16210410
    5. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables steroid dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retinol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    retinol dehydrogenase 14
    Names
    retinol dehydrogenase 14 (all-trans and 9-cis)
    retinol dehydrogenase 14 (all-trans and 9-cis)9
    retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
    NP_001102746.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109276.1 → NP_001102746.1  retinol dehydrogenase 14

      See identical proteins and their annotated locations for NP_001102746.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HAN7, D3ZUY0
      Related
      ENSRNOP00000006020.4, ENSRNOT00000006020.8
      Conserved Domains (2) summary
      PRK06197
      Location:43 → 332
      PRK06197; short chain dehydrogenase; Provisional
      cl21454
      Location:44 → 326
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      38875693..38880836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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