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    Elp4 elongator acetyltransferase complex subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687694, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elp4provided by RGD
    Official Full Name
    elongator acetyltransferase complex subunit 4provided by RGD
    Primary source
    RGD:1566052
    See related
    EnsemblRapid:ENSRNOG00000004787 AllianceGenome:RGD:1566052
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566052
    Summary
    Predicted to enable phosphorylase kinase regulator activity. Predicted to contribute to RNA polymerase II complex binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of elongator holoenzyme complex and transcription elongation factor complex. Human ortholog(s) of this gene implicated in aniridia. Orthologous to human ELP4 (elongator acetyltransferase complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 52.2), Thymus (RPKM 46.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elp4 in Genome Data Viewer
    Location:
    3q33
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (112617020..112839963, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (92162271..92385251, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (95733810..95954987, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene thioesterase superfamily member 7 Neighboring gene reticulocalbin 1 Neighboring gene paired box 6 Neighboring gene ribosomal protein L35A like 6 Neighboring gene uncharacterized LOC120101618 Neighboring gene U2 spliceosomal RNA Neighboring gene inner mitochondrial membrane peptidase subunit 1 Neighboring gene DnaJ heat shock protein family (Hsp40) member C24

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of the human elongator complex. Hawkes NA, et al. J Biol Chem, 2002 Jan 25. PMID 11714725
    2. Human Elongator facilitates RNA polymerase II transcription through chromatin. Kim JH, et al. Proc Natl Acad Sci U S A, 2002 Feb 5. PMID 11818576, Free PMC Article
    3. DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator. Close P, et al. J Biol Chem, 2012 Sep 21. PMID 22854966, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to RNA polymerase II complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphorylase kinase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    elongator complex protein 4
    Names
    elongation protein 4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115047.2 → NP_001108519.1  elongator complex protein 4

      See identical proteins and their annotated locations for NP_001108519.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158667
      UniProtKB/TrEMBL
      A0A8I6A5H6, B0BN35
      Conserved Domains (1) summary
      pfam05625
      Location:28 → 404
      PAXNEB; PAXNEB protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      112617020..112839963 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105869.2 → XP_038961797.1  elongator complex protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A5H6, F1M086
      Related
      ENSRNOP00000006385.8, ENSRNOT00000006385.9
      Conserved Domains (1) summary
      pfam05625
      Location:44 → 423
      PAXNEB; PAXNEB protein

    2. XM_039105870.2 → XP_038961798.1  elongator complex protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A5H6
      Conserved Domains (1) summary
      pfam05625
      Location:44 → 381
      PAXNEB; PAXNEB protein

    3. XM_063284571.1 → XP_063140641.1  elongator complex protein 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A5H6
      Related
      ENSRNOP00000087949.2, ENSRNOT00000097695.2

    4. XM_063284570.1 → XP_063140640.1  elongator complex protein 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A5H6
      Related
      ENSRNOP00000103642.1, ENSRNOT00000148973.1

    5. XM_039105871.2 → XP_038961799.1  elongator complex protein 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A5H6
      Conserved Domains (1) summary
      pfam05625
      Location:44 → 380
      PAXNEB; PAXNEB protein

    RNA

    1. XR_005501986.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials