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    Mtpap mitochondrial poly(A) polymerase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307050, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtpapprovided by RGD
    Official Full Name
    mitochondrial poly(A) polymeraseprovided by RGD
    Primary source
    RGD:1310900
    See related
    EnsemblRapid:ENSRNOG00000016578 AllianceGenome:RGD:1310900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Papd1
    Summary
    Predicted to enable several functions, including metal ion binding activity; poly(A) RNA polymerase activity; and ribonucleotide binding activity. Predicted to be involved in histone mRNA catabolic process and mitochondrial RNA 3'-end processing. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 90.7), Kidney (RPKM 83.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtpap in Genome Data Viewer
    Location:
    17q12.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (58015979..58036735, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (53320739..53341500, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (56046507..56068185, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348576 Neighboring gene uncharacterized LOC120097757 Neighboring gene uncharacterized LOC134482858 Neighboring gene mitogen-activated protein kinase kinase kinase 8 Neighboring gene ribosomal protein L27A like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Bai Y, et al. Mol Cell, 2011 Feb 4. PMID 21292163, Free PMC Article
    2. Defective mitochondrial mRNA maturation is associated with spastic ataxia. Crosby AH, et al. Am J Hum Genet, 2010 Nov 12. PMID 20970105, Free PMC Article
    3. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. Mullen TE, et al. Genes Dev, 2008 Jan 1. PMID 18172165, Free PMC Article
    4. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UTP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in histone mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    poly(A) RNA polymerase, mitochondrial
    Names
    PAP associated domain containing 1
    NP_001386242.1
    NP_001386243.1
    XP_038951675.1
    XP_063132550.1
    XP_063132551.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399313.1 → NP_001386242.1  poly(A) RNA polymerase, mitochondrial isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      D3ZPN5
      Related
      ENSRNOP00000022462.6, ENSRNOT00000022462.8
      Conserved Domains (3) summary
      cd05402
      Location:209 → 347
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:184 → 496
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam17797
      Location:63 → 132
      RL; RL domain

    2. NM_001399314.1 → NP_001386243.1  poly(A) RNA polymerase, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      D3ZPN5
      Conserved Domains (3) summary
      cd05402
      Location:205 → 343
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:180 → 492
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
      pfam17797
      Location:59 → 128
      RL; RL domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      58015979..58036735 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276480.1 → XP_063132550.1  poly(A) RNA polymerase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y4F0, A0A8I6A369, A6K9G0

    2. XM_063276481.1 → XP_063132551.1  poly(A) RNA polymerase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y4F0, A0A8I6A369, A6K9G0

    3. XM_039095747.2 → XP_038951675.1  poly(A) RNA polymerase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y4F0, A0A8I6A369, A6K9G0
      Related
      ENSRNOP00000076406.1, ENSRNOT00000099525.2
      Conserved Domains (2) summary
      cd05402
      Location:28 → 99
      NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
      COG5260
      Location:57 → 248
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    RNA

    1. XR_005495287.2 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107359.1: Suppressed sequence

      Description
      NM_001107359.1: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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