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    Pgm5 phosphoglucomutase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679990, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pgm5provided by RGD
    Official Full Name
    phosphoglucomutase 5provided by RGD
    Primary source
    RGD:1307969
    See related
    EnsemblRapid:ENSRNOG00000015406 AllianceGenome:RGD:1307969
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable magnesium ion binding activity and phosphoglucomutase activity. Predicted to be involved in carbohydrate metabolic process; myofibril assembly; and striated muscle tissue development. Predicted to be located in several cellular components, including focal adhesion; myofibril; and spot adherens junction. Predicted to be part of dystrophin-associated glycoprotein complex. Predicted to be active in several cellular components, including adherens junction; cell-substrate junction; and sarcolemma. Orthologous to human PGM5 (phosphoglucomutase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 326.3), Uterus (RPKM 281.0) and 7 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pgm5 in Genome Data Viewer
    Location:
    1q51
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (231752052..231939812, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (222325638..222513434, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (242582591..242765837, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 beta Neighboring gene dynein light chain Tctex-type 1, pseudogene1 Neighboring gene transmembrane protein 252 Neighboring gene uncharacterized LOC102556915 Neighboring gene forkhead box D4 Neighboring gene Zn regulated GTPase metalloprotein activator 1A

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables intramolecular phosphotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables phosphoglucomutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphoglucomutase activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT enables phosphoglucomutase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myofibril assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in striated muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Z disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-substrate junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-substrate junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in costamere IEA
    Inferred from Electronic Annotation
    more info
     
    located_in costamere ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of dystrophin-associated glycoprotein complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of dystrophin-associated glycoprotein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intercalated disc IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercalated disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spot adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in spot adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phosphoglucomutase-like protein 5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191953.3NP_001178882.1  phosphoglucomutase-like protein 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      D3ZVR9
      UniProtKB/TrEMBL
      A0A8I6AHF8
      Related
      ENSRNOP00000092363.1, ENSRNOT00000112231.2
      Conserved Domains (1) summary
      cl38939
      Location:10567
      phosphohexomutase; The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      231752052..231939812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273533.1XP_063129603.1  phosphoglucomutase-like protein 5 isoform X1

      UniProtKB/TrEMBL
      A6I0Q9