Irs3 insulin receptor substrate 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Irs3provided by RGD
Official Full Name: insulin receptor substrate 3provided by RGD
Primary source: RGD:69317
See related: EnsemblRapid:ENSRNOG00000001389 AllianceGenome:RGD:69317
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable insulin receptor binding activity and phosphatidylinositol 3-kinase binding activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be active in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 37.2), Liver (RPKM 29.5) and 9 other tissues See more
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Genomic context

Location:: 12q12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (24689930..24692068)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (19053148..19055286)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (22120305..22125103)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

53BP2S interacts and modulates the insulin signals mediated by insulin receptor substrates.
Title: 53BP2S, interacting with insulin receptor substrates, modulates insulin signaling.
These results suggest that intracellular localization of IRS-3 is determined by a different mechanism from other IRS proteins, and that IRS-3 possesses a transcription-regulating activity
Title: Insulin receptor substrate-3 functions as transcriptional activator in the nucleus.
Cyclic GMP-dependent protein kinase increases the DNA binding potential of C/EBPbeta by preventing the negative effects of GSK-3 phosphorylation
Title: Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3.
IRS-3 expression blocked glucose/IGF-1 induced IRS-2 translocation from the cytosol to the plasma membrane, dampening IRS-2/IGF-1R interaction and subsequent activation of the PI3K/PKB/GSK3 signaling pathway
Title: IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
IRS-3 may play a unique role in mitogenesis by inhibiting insulin-stimulated cell cycle progression via a decrease in cyclin D1 and p21 expressions as well as suppression of c-myc mRNA induction
Title: Insulin-induced cell cycle progression is impaired in chinese hamster ovary cells overexpressing insulin receptor substrate-3.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC86565P2 (e-PCR)
- UniSTS:273535

RH131481 (e-PCR)
- UniSTS:214764

RH94802 (e-PCR)
- UniSTS:120048

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables insulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables insulin receptor binding	TAS Traceable Author Statement more info	PubMed
enables phosphatidylinositol 3-kinase activator activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: insulin receptor substrate 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032074.1 → NP_114463.1 insulin receptor substrate 3

See identical proteins and their annotated locations for NP_114463.1

Status: PROVISIONAL

Source sequence(s)

U93880

UniProtKB/TrEMBL

B1WBQ1, F7F0S6, O08724

Related

ENSRNOP00000001874.1, ENSRNOT00000001874.4

Conserved Domains (3) summary

cd01204
Location:159 → 273

PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)

cd01257
Location:32 → 132

PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain

pfam00169
Location:33 → 131

PH; PH domain