STAT1 signal transducer and activator of transcription 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: STAT1provided by HGNC
Official Full Name: signal transducer and activator of transcription 1provided by HGNC
Primary source: HGNC:HGNC:11362
See related: Ensembl:ENSG00000115415 MIM:600555; AllianceGenome:HGNC:11362
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91
Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in lymph node (RPKM 79.1), appendix (RPKM 72.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q32.2

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (190969149..191014171, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (191458256..191503284, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (191833875..191878897, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
Title: The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy.
STAT1 and STAT3 gain of function: clinically heterogenous immune regulatory disorders.
Title: STAT1 and STAT3 gain of function: clinically heterogenous immune regulatory disorders.
Regulation of STAT1 Signaling in Human Pancreatic beta-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?
Title: Regulation of STAT1 Signaling in Human Pancreatic β-Cells by the Lysine Deacetylase HDAC6: A New Therapeutic Opportunity in Type 1 Diabetes?
Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjogren's syndrome: Novel biomarkers for disease activity and subsets.
Title: Elevated unphosphorylated STAT1 and IRF9 in T and B cells of primary sjögren's syndrome: Novel biomarkers for disease activity and subsets.
CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis.
Title: CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis.
AIM2 inflammasome regulated by the IFN-gamma/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease.
Title: AIM2 inflammasome regulated by the IFN-γ/JAK2/STAT1 pathway promotes activation and pyroptosis of monocytes in Coronary Artery Disease.
KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
Title: KAT7 serves as an oncogenic gene and regulates CCL3 expression via STAT1 signaling in osteosarcoma.
Qualitative Immunoglobulin Deficiency Causes Bacterial Infections in Patients with STAT1 Gain-of-Function Mutations.
Title: Qualitative Immunoglobulin Deficiency Causes Bacterial Infections in Patients with STAT1 Gain-of-Function Mutations.
Unveiling the role of HP1alpha-HDAC1-STAT1 axis as a therapeutic target for HP1alpha-positive intrahepatic cholangiocarcinoma.
Title: Unveiling the role of HP1α-HDAC1-STAT1 axis as a therapeutic target for HP1α-positive intrahepatic cholangiocarcinoma.
STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma.
Title: STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma.

Submit: New GeneRIF Correction See all GeneRIFs (809)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autoimmune enteropathy and endocrinopathy - susceptibility to chronic infections syndrome MedGen: C3279990 OMIM: 614162 GeneReviews: Not available	not available
Immunodeficiency 31B MedGen: C3151088 OMIM: 613796 GeneReviews: Not available	not available
Mendelian susceptibility to mycobacterial diseases due to partial STAT1 deficiency MedGen: C4013950 OMIM: 614892 GeneReviews: Not available	not available

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2013-09-18) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2013-09-18) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infection upregulates basal mRNA levels of JUN, IL6, STAT1, CEBPA, RELA, and CEBPG in monocyte derived macrophages	PubMed
HIV/tuberculosis coinfection upregulates STAT1 expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with tuberculosis only)	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Monocyte-derived dendritic cells treated with HIV-1 gp120 (CCR5-tropic, CN54) upregulates STAT1 expression at 18 hours post-treatment	PubMed
	env	HIV-1 gp120 activates both STAT1 and STAT2 in primary human monocyte-derived dendritic cells	PubMed
	env	Signal transducer and activator of transcription factor 1 (STAT1) partially regulates HIV-1 gp120/HCV E2-induced caspase 3 activity	PubMed
Nef	nef	HIV-1 Nef-induced tyrosine-hyperphosphorylation of STAT1 is inhibited by the presence of retinoic acid in monocyte-derived DCs	PubMed
	nef	TRAF2 and TRAF6 proteins are required for the HIV-1 Nef-induced tyrosine phosphorylation of STAT1 and STAT2 proteins. Both myristoylation and acidic cluster of Nef are essential to induce the tyrosine phosphorylation	PubMed
	nef	HIV-1 Nef induces phosphorylation of STAT1 in M2-type macrophages	PubMed
	nef	HIV-1 Nef specifically activates both alpha and beta isoforms of the signal transducer and activator of transcription 1 (STAT1) in human monocyte-derived macrophages (MDMs)	PubMed
Tat	tat	HIV-1 Tat increases phosphorylation of ERK1/2, JNK1/2, p38, AKT1, MEK-1, and STAT-1alpha in Muller glia	PubMed
	tat	HIV-1 and the viral protein Tat modulate the expression of signal transducer and activator of transcription 1, 91kDa (STAT1) in immature dendritic cells and monocyte-derived macrophages	PubMed
	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including STAT-1 (p91 and p84), in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed
	tat	HIV-1 Tat suppresses IFN-gamma-induced LC3B protein expression and autophagosome formation through Tat-mediated suppression of STAT1 phosphorylation	PubMed
	tat	HIV-1 Tat impairs the IFNgamma-receptor signaling pathway, in primary human monocytes, at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity	PubMed
	tat	HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha	PubMed
	tat	HIV-1 Tat represses transcription of the LMP2 gene by competing with STAT1 (signal transducer and activator of transcription 1) for binding to IRF-1 (interferon-regulatory factor-1) at the LMP2 promoter	PubMed
Vpr	vpr	HIV-1 Vpr induces the phosphorylation of STAT1 at tyrosine 701 and upregulates the expression of STAT1 in human monocyte-derived macrophages	PubMed
	vpr	HIV-1 Vpr enhances TNF-alpha production in LPS-stimulated dendritic cells (DC). Vpr-induced TNF-alpha production in DC is through STAT1 activation	PubMed
Vpu	vpu	The expression of STAT1 is enhanced in Vpu-deficient HIV-1-infected cells as compared to that in wild-type-infected cells	PubMed
matrix	gag	HIV-1 MA recruits STAT1 to the LXR promoter region containing the STAT responsive sequence TTCAGGGAA; STAT1 mediates upregulation of NR1H3 (LXR-alpha) gene expression	PubMed
	gag	HIV-1 MA increases phosphorylation of STAT1	PubMed
	gag	HIV-1 MA natural variant S75X upregulates the expression of STAT1 and STAT3, and induces phosphorylation of STAT1 at position S727 and STAT3 at position Y705 in Epstein-Barr virus (EBV)-infected B-lymphocytes	PubMed
	gag	Treatment of human stellate cells with HIV-1 MA induces phosphorylation of STAT1 and STAT3 proteins	PubMed
	gag	Exposure of human acute monocytic leukemia cells THP-1 to HIV-1 MA activates the syndecan-2/RACK-1/Jak-1 signal pathway, leading to STAT-1 phosphorylation	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STAT1_425 (e-PCR)
- UniSTS:277772

RH36288 (e-PCR)
- UniSTS:2578

STS-N69004 (e-PCR)
- UniSTS:56649

G67903 (e-PCR)
- UniSTS:225635

G67906 (e-PCR)
- UniSTS:225636

G67907 (e-PCR)
- UniSTS:225637

G67904 (e-PCR)
- UniSTS:225638

G67905 (e-PCR)
- UniSTS:225639

G67909 (e-PCR)
- UniSTS:225640

G67908 (e-PCR)
- UniSTS:225642

G67910 (e-PCR)
- UniSTS:225643

G67912 (e-PCR)
- UniSTS:225644

G67913 (e-PCR)
- UniSTS:225645

G67914 (e-PCR)
- UniSTS:225646

RH78038 (e-PCR)
- UniSTS:13214

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables CCR5 chemokine receptor binding	IEA Inferred from Electronic Annotation more info
NOT enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II core promoter sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	HDA more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone acetyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables histone binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 2A binding	IEA Inferred from Electronic Annotation more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor binding	IPI Inferred from Physical Interaction more info	PubMed
enables tumor necrosis factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-like protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in blood circulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IDA Inferred from Direct Assay more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interferon-beta	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to interferon-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
involved_in cellular response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-27-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-7-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-9-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in metanephric mesenchymal cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephric mesenchymal cell proliferation involved in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation by virus of viral protein levels in host cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical NF-kappaB signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of metanephric nephron tubule epithelial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of defense response to virus by host	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of defense response to virus by host	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interferon-alpha production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of mesenchymal cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in renal tubule development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cytokine	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
involved_in response to interferon-beta	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IEA Inferred from Electronic Annotation more info
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to type II interferon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type I interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in type II interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type II interferon-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ISGF3 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ISGF3 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	NAS Non-traceable Author Statement more info	PubMed
located_in axon	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in dendrite	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IC Inferred by Curator more info	PubMed
colocalizes_with nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: signal transducer and activator of transcription 1-alpha/beta

Names: signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1, 91kDa; transcription factor ISGF-3 components p91/p84

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008294.1 RefSeqGene

Range

5001..50215

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_111

mRNA and Protein(s)

NM_001384880.1 → NP_001371809.1 signal transducer and activator of transcription 1-alpha/beta isoform 1

Status: REVIEWED

Source sequence(s)

AC067945

Consensus CDS

CCDS92917.1

UniProtKB/TrEMBL

A0A669KB56, A0A8V8TN81

Related

ENSP00000513583.1, ENST00000698142.1

Conserved Domains (5) summary

cd10372
Location:537 → 687

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cl28920
Location:317 → 457

STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)

pfam12162
Location:695 → 719

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001384881.1 → NP_001371810.1 signal transducer and activator of transcription 1-alpha/beta isoform 2

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB56

Conserved Domains (5) summary

cd10372
Location:559 → 709

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:4 → 123

STAT_int; STAT protein, protein interaction domain

cd16851
Location:140 → 315

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:319 → 479

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:717 → 741

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001384882.1 → NP_001371811.1 signal transducer and activator of transcription 1-alpha/beta isoform 3

Status: REVIEWED

Source sequence(s)

AC067945

Consensus CDS

CCDS92918.1

UniProtKB/TrEMBL

A0A669KB56, A0A669KB68

Related

ENSP00000501145.1, ENST00000673942.1

Conserved Domains (5) summary

cd10372
Location:555 → 705

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 475

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:713 → 737

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001384883.1 → NP_001371812.1 signal transducer and activator of transcription 1-alpha/beta isoform 4

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB56

Conserved Domains (5) summary

cd10372
Location:524 → 674

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

cd16845
Location:284 → 444

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cl28921
Location:62 → 280

STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain

pfam12162
Location:682 → 706

STAT1_TAZ2bind; STAT1 TAZ2 binding domain

pfam02865
Location:2 → 120

STAT_int; STAT protein, protein interaction domain
NM_001384884.1 → NP_001371813.1 signal transducer and activator of transcription 1-alpha/beta isoform 5

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB52

Conserved Domains (4) summary

smart00964
Location:4 → 123

STAT_int; STAT protein, protein interaction domain

cd16851
Location:140 → 315

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:319 → 479

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cl15255
Location:559 → 655

SH2; Src homology 2 (SH2) domain
NM_001384885.1 → NP_001371814.1 signal transducer and activator of transcription 1-alpha/beta isoform 6

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB56

Conserved Domains (5) summary

cd10372
Location:504 → 654

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16845
Location:264 → 424

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cl28921
Location:138 → 261

STAT_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription (STAT), also called alpha domain

pfam12162
Location:662 → 686

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001384886.1 → NP_001371815.1 signal transducer and activator of transcription 1-alpha/beta isoform 7

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB56

Conserved Domains (5) summary

cd10372
Location:557 → 715

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:723 → 747

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001384887.1 → NP_001371816.1 signal transducer and activator of transcription 1-alpha/beta isoform 8

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB56

Conserved Domains (5) summary

cd10372
Location:526 → 676

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cl28920
Location:315 → 446

STAT_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription (STAT)

pfam12162
Location:684 → 708

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001384888.1 → NP_001371817.1 signal transducer and activator of transcription 1-alpha/beta isoform 9

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB56

Conserved Domains (5) summary

cd10372
Location:547 → 697

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 467

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:705 → 729

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001384889.1 → NP_001371818.1 signal transducer and activator of transcription 1-alpha/beta isoform 10

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB56

Related

ENSP00000513587.1, ENST00000698149.1

Conserved Domains (5) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:713 → 735

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001384890.1 → NP_001371819.1 signal transducer and activator of transcription 1-alpha/beta isoform 11

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB56

Conserved Domains (5) summary

cd10372
Location:527 → 677

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:124 → 283

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:287 → 447

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:685 → 709

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_001384891.1 → NP_001371820.1 signal transducer and activator of transcription 1-alpha/beta isoform 12

Status: REVIEWED

Source sequence(s)

AC067945

UniProtKB/TrEMBL

A0A669KB56

Conserved Domains (5) summary

cd10372
Location:569 → 719

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 133

STAT_int; STAT protein, protein interaction domain

cd16851
Location:150 → 325

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:329 → 489

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:727 → 751

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_007315.4 → NP_009330.1 signal transducer and activator of transcription 1-alpha/beta isoform alpha

See identical proteins and their annotated locations for NP_009330.1

Status: REVIEWED

Description

Transcript Variant: This variant (alpha) encodes isoform alpha.

Source sequence(s)

AI992149, AK292604, AK315002, BU738296, CN410740, CR749636, CR998778, EB385742

Consensus CDS

CCDS2309.1

UniProtKB/Swiss-Prot

A8K989, B2RCA0, D2KFR8, D3DPI7, P42224, Q53S88, Q53XW4, Q68D00, Q9UDL5

UniProtKB/TrEMBL

A0A669KB56

Related

ENSP00000354394.4, ENST00000361099.8

Conserved Domains (5) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:715 → 739

STAT1_TAZ2bind; STAT1 TAZ2 binding domain
NM_139266.3 → NP_644671.1 signal transducer and activator of transcription 1-alpha/beta isoform beta

See identical proteins and their annotated locations for NP_644671.1

Status: REVIEWED

Description

Transcript Variant: This variant (beta) is different in its 3' coding region and UTR compared to variant alpha. It encodes a protein (isoform beta) with a shorter C-terminus, when compared to isoform alpha.

Source sequence(s)

BX400908, CR749636, CR998778

Consensus CDS

CCDS42793.1

UniProtKB/TrEMBL

J3KPM9

Related

ENSP00000376136.3, ENST00000392322.7

Conserved Domains (4) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

pfam01017
Location:139 → 315

STAT_alpha; STAT protein, all-alpha domain

pfam02864
Location:317 → 566

STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

190969149..191014171 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006712718.2 → XP_006712781.1 signal transducer and activator of transcription 1-alpha/beta isoform X1

See identical proteins and their annotated locations for XP_006712781.1

UniProtKB/Swiss-Prot

A8K989, B2RCA0, D2KFR8, D3DPI7, P42224, Q53S88, Q53XW4, Q68D00, Q9UDL5

UniProtKB/TrEMBL

A0A669KB56

Related

ENSP00000438703.2, ENST00000540176.6

Conserved Domains (5) summary

cd10372
Location:557 → 707

SH2_STAT1; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 1 proteins

smart00964
Location:2 → 121

STAT_int; STAT protein, protein interaction domain

cd16851
Location:138 → 313

STAT1_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 1 (STAT1)

cd16845
Location:317 → 477

STAT1_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 1 (STAT1)

pfam12162
Location:715 → 739

STAT1_TAZ2bind; STAT1 TAZ2 binding domain