Sypl1 synaptophysin like 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sypl1provided by MGI
Official Full Name: synaptophysin like 1provided by MGI
Primary source: MGI:MGI:108081
See related: Ensembl:ENSMUSG00000020570 AllianceGenome:MGI:108081
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PanI; Pphn; Sypl; D12Ertd446e
Summary: Located in membrane and secretory granule. Is expressed in neocortex. Orthologous to human SYPL1 (synaptophysin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 15.7), testis adult (RPKM 11.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 13.87 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (33003874..33029503)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (32953855..32979502)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility.
Title: SYPL1 defines a vesicular pathway essential for sperm cytoplasmic droplet formation and male fertility.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (3)

General gene information

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Markers

AI604763 (e-PCR)
- UniSTS:180384

D12Ertd446e (e-PCR), detects polymorphism
- UniSTS:167088

AI314763 (e-PCR)
- UniSTS:160199

Gene Ontology Provided by MGI

Component	Evidence Code	Pubs
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: synaptophysin-like protein 1

Names: Pan I; pantophysin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013635.3 → NP_038663.2 synaptophysin-like protein 1 isoform 1

See identical proteins and their annotated locations for NP_038663.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC155258, BC060971

Consensus CDS

CCDS25872.1

UniProtKB/Swiss-Prot

O09117, Q8BQI8, Q8BQJ1, Q8C749

UniProtKB/TrEMBL

Q3U4T9

Related

ENSMUSP00000075990.6, ENSMUST00000076698.13

Conserved Domains (1) summary

pfam01284
Location:110 → 233

MARVEL; Membrane-associating domain
NM_198710.3 → NP_942003.1 synaptophysin-like protein 1 isoform 2

See identical proteins and their annotated locations for NP_942003.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a segment of the 5' UTR and 5' coding region, compared to variant 1. These differences result in a unique 5' UTR and a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC155258, AK049556, BB847647

Consensus CDS

CCDS25873.1

UniProtKB/TrEMBL

Q3TVX7, Q3U4T9

Related

ENSMUSP00000020885.7, ENSMUST00000020885.13

Conserved Domains (1) summary

pfam01284
Location:92 → 215

MARVEL; Membrane-associating domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

33003874..33029503

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243842.3 → XP_011242144.1 synaptophysin-like protein 1 isoform X1
XM_011243843.3 → XP_011242145.1 synaptophysin-like protein 1 isoform X2
XM_036157254.1 → XP_036013147.1 synaptophysin-like protein 1 isoform X3

Conserved Domains (1) summary

pfam01284
Location:1 → 81

MARVEL; Membrane-associating domain