Phldb2 pleckstrin homology like domain, family B, member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Phldb2provided by MGI
Official Full Name: pleckstrin homology like domain, family B, member 2provided by MGI
Primary source: MGI:MGI:2444981
See related: Ensembl:ENSMUSG00000033149 AllianceGenome:MGI:2444981
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LL5b; LL5beta; C820004H04Rik
Summary: Involved in cell migration and establishment of cell polarity. Predicted to be located in several cellular components, including cell leading edge; cytoskeleton; and cytosol. Predicted to be active in basal cortex. Predicted to colocalize with focal adhesion. Is expressed in cerebral cortex subventricular zone and cerebral cortex ventricular layer. Orthologous to human PHLDB2 (pleckstrin homology like domain family B member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bladder adult (RPKM 19.0), limb E14.5 (RPKM 13.1) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B5; 16 30.08 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (45566593..45773961, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (45746230..45953598, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner.
Title: Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner.
PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.
Title: PIP(3)-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.
A transport system, organized by agrin through PI3 kinase, GSK3beta, CLASP2, and LL5beta, for precise delivery of acetylcholine receptor vesicles from subsynaptic nuclei to overlying synaptic membrane was identified at neuromuscular junction membrane.
Title: CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles.
These results provide evidence for an important contribution of the BMP2-PI3K (p55gamma/p110alpha)- PIP3-LL5beta signalling axis in mesenchymal progenitor cell chemotaxis.
Title: BMP2-induced chemotaxis requires PI3K p55γ/p110α-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5β recruitment at the cytocortex.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW742898 (e-PCR)
- UniSTS:209223

AV253284 (e-PCR)
- UniSTS:180920

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of cell polarity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of protein localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of wound healing, spreading of epidermal cells	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of gastrulation	IEA Inferred from Electronic Annotation more info
involved_in regulation of gastrulation	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basal cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in basal cortex	IEA Inferred from Electronic Annotation more info
located_in basal cortex	ISO Inferred from Sequence Orthology more info
located_in cell leading edge	IEA Inferred from Electronic Annotation more info
located_in cell leading edge	ISO Inferred from Sequence Orthology more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	IEA Inferred from Electronic Annotation more info
colocalizes_with focal adhesion	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: pleckstrin homology-like domain family B member 2

Names: protein LL5-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252442.1 → NP_001239371.1 pleckstrin homology-like domain family B member 2 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK087133, AK165251, BB851780, BC050915, BY442240

Consensus CDS

CCDS57031.1

UniProtKB/TrEMBL

D3Z069

Related

ENSMUSP00000075672.6, ENSMUST00000076333.12

Conserved Domains (4) summary

cd14673
Location:1191 → 1295

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00169
Location:1194 → 1290

PH; PH domain

cl02488
Location:597 → 786

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl19107
Location:1085 → 1155

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
NM_001357078.1 → NP_001344007.1 pleckstrin homology-like domain family B member 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC164979, AC166572

UniProtKB/TrEMBL

D3Z069

Conserved Domains (4) summary

TIGR00618
Location:523 → 1070

sbcc; exonuclease SbcC

COG1196
Location:575 → 767

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1095 → 1199

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:987 → 1054

DUF5401; Family of unknown function (DUF5401)
NM_153412.4 → NP_700461.2 pleckstrin homology-like domain family B member 2 isoform 2

See identical proteins and their annotated locations for NP_700461.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC164979, AC166572

Consensus CDS

CCDS28202.1

UniProtKB/Swiss-Prot

Q3TNI3, Q80Y16, Q8BKV3, Q8K1N2

UniProtKB/TrEMBL

D3Z069

Related

ENSMUSP00000046496.7, ENSMUST00000036355.13

Conserved Domains (4) summary

cd14673
Location:1138 → 1242

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00169
Location:1141 → 1237

PH; PH domain

cl02488
Location:597 → 786

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

cl19107
Location:1032 → 1102

SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

45566593..45773961 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159845.1 → XP_036015738.1 pleckstrin homology-like domain family B member 2 isoform X20

UniProtKB/TrEMBL

F6QU68, Q8BZE3

Related

ENSMUSP00000119718.2, ENSMUST00000131003.8

Conserved Domains (3) summary

cd14673
Location:507 → 611

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

TIGR02168
Location:30 → 180

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17380
Location:399 → 466

DUF5401; Family of unknown function (DUF5401)
XM_006521926.4 → XP_006521989.1 pleckstrin homology-like domain family B member 2 isoform X7

See identical proteins and their annotated locations for XP_006521989.1

UniProtKB/TrEMBL

D3Z069

Related

ENSMUSP00000123284.2, ENSMUST00000134802.8

Conserved Domains (3) summary

COG1196
Location:584 → 847

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1183 → 1287

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam02463
Location:626 → 1168

SMC_N; RecF/RecN/SMC N terminal domain
XM_006521921.4 → XP_006521984.1 pleckstrin homology-like domain family B member 2 isoform X2

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:580 → 843

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1240 → 1344

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00769
Location:1132 → 1205

ERM; Ezrin/radixin/moesin family
XM_030249020.1 → XP_030104880.1 pleckstrin homology-like domain family B member 2 isoform X15

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:620 → 841

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1092 → 1196

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:987 → 1055

DUF5401; Family of unknown function (DUF5401)
XM_006521928.4 → XP_006521991.1 pleckstrin homology-like domain family B member 2 isoform X10

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

TIGR00618
Location:568 → 1115

sbcc; exonuclease SbcC

COG1196
Location:620 → 812

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1140 → 1244

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
XM_006521923.4 → XP_006521986.1 pleckstrin homology-like domain family B member 2 isoform X5

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:620 → 812

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1201 → 1305

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00769
Location:1093 → 1166

ERM; Ezrin/radixin/moesin family
XM_036159842.1 → XP_036015735.1 pleckstrin homology-like domain family B member 2 isoform X17

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:584 → 847

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1088 → 1192

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

TIGR02168
Location:712 → 1053

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_006521929.4 → XP_006521992.1 pleckstrin homology-like domain family B member 2 isoform X11

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG0419
Location:628 → 1094

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:584 → 847

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1135 → 1239

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
XM_006521927.4 → XP_006521990.1 pleckstrin homology-like domain family B member 2 isoform X8

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG0419
Location:628 → 1119

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

COG1196
Location:584 → 847

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1160 → 1264

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
XM_011245859.3 → XP_011244161.1 pleckstrin homology-like domain family B member 2 isoform X3

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:584 → 847

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1221 → 1325

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam15921
Location:642 → 1172

CCDC158; Coiled-coil domain-containing protein 158
XM_006521920.4 → XP_006521983.1 pleckstrin homology-like domain family B member 2 isoform X1

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:584 → 847

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1244 → 1348

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:1139 → 1207

DUF5401; Family of unknown function (DUF5401)
XM_030249019.1 → XP_030104879.1 pleckstrin homology-like domain family B member 2 isoform X2

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:580 → 843

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1240 → 1344

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam00769
Location:1132 → 1205

ERM; Ezrin/radixin/moesin family
XM_006521925.5 → XP_006521988.1 pleckstrin homology-like domain family B member 2 isoform X6

See identical proteins and their annotated locations for XP_006521988.1

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:539 → 802

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1199 → 1303

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:1094 → 1162

DUF5401; Family of unknown function (DUF5401)
XM_006521922.5 → XP_006521985.1 pleckstrin homology-like domain family B member 2 isoform X4

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:550 → 813

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1210 → 1314

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:1105 → 1173

DUF5401; Family of unknown function (DUF5401)
XM_036159837.1 → XP_036015730.1 pleckstrin homology-like domain family B member 2 isoform X9

Conserved Domains (3) summary

COG1196
Location:575 → 767

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1156 → 1260

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:1048 → 1115

DUF5401; Family of unknown function (DUF5401)
XM_006521924.5 → XP_006521987.1 pleckstrin homology-like domain family B member 2 isoform X6

See identical proteins and their annotated locations for XP_006521987.1

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:539 → 802

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1199 → 1303

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:1094 → 1162

DUF5401; Family of unknown function (DUF5401)
XM_036159839.1 → XP_036015732.1 pleckstrin homology-like domain family B member 2 isoform X13

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

TIGR00618
Location:534 → 1081

sbcc; exonuclease SbcC

COG1196
Location:586 → 778

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1106 → 1210

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain
XM_036159843.1 → XP_036015736.1 pleckstrin homology-like domain family B member 2 isoform X18

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:575 → 796

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1047 → 1151

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:939 → 1006

DUF5401; Family of unknown function (DUF5401)
XM_036159840.1 → XP_036015733.1 pleckstrin homology-like domain family B member 2 isoform X14

UniProtKB/TrEMBL

D3Z069

Conserved Domains (4) summary

TIGR00618
Location:523 → 1070

sbcc; exonuclease SbcC

COG1196
Location:575 → 767

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1095 → 1199

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:987 → 1054

DUF5401; Family of unknown function (DUF5401)
XM_036159841.1 → XP_036015734.1 pleckstrin homology-like domain family B member 2 isoform X16

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:539 → 802

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1090 → 1194

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:982 → 1049

DUF5401; Family of unknown function (DUF5401)
XM_036159838.1 → XP_036015731.1 pleckstrin homology-like domain family B member 2 isoform X12

UniProtKB/TrEMBL

D3Z069

Conserved Domains (3) summary

COG1196
Location:539 → 802

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd14673
Location:1115 → 1219

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

pfam17380
Location:1007 → 1074

DUF5401; Family of unknown function (DUF5401)
XM_036159844.1 → XP_036015737.1 pleckstrin homology-like domain family B member 2 isoform X19

Conserved Domains (3) summary

cd14673
Location:568 → 672

PH_PHLDB1_2; Pleckstrin homology-like domain-containing family B member 2 pleckstrin homology (PH) domain

TIGR02168
Location:30 → 180

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam17380
Location:460 → 527

DUF5401; Family of unknown function (DUF5401)