MAE1 malate dehydrogenase (oxaloacetate-decarboxylating) [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MAE1
Official Full Name: malate dehydrogenase (oxaloacetate-decarboxylating)
Primary source: SGD:S000001512
Locus tag: YKL029C
See related: AllianceGenome:SGD:S000001512; FungiDB:YKL029C; VEuPathDB:YKL029C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables malic enzyme activity. Involved in amino acid metabolic process and pyruvate metabolic process. Located in mitochondrion. Orthologous to human ME1 (malic enzyme 1); ME2 (malic enzyme 2); and ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MAE1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (382716..384725, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables malate dehydrogenase (decarboxylating) (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables malate dehydrogenase (decarboxylating) (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables malic enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables malic enzyme activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxaloacetate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in amino acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyruvate metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: malate dehydrogenase (oxaloacetate-decarboxylating)

NP_012896.1

EC 1.1.1.38

Mitochondrial malic enzyme; catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

382716..384725 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179595.1 → NP_012896.1 TPA: malate dehydrogenase (oxaloacetate-decarboxylating) [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012896.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXQ5, P36013

UniProtKB/TrEMBL

G2WI00

Conserved Domains (1) summary

PRK13529
Location:91 → 658

PRK13529; oxaloacetate-decarboxylating malate dehydrogenase