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    RPS20 ribosomal 40S subunit protein S20 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856371, updated on 3-Nov-2024

    Summary

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    Official Symbol
    RPS20
    Official Full Name
    ribosomal 40S subunit protein S20
    Primary source
    SGD:S000001007
    Locus tag
    YHL015W
    See related
    AllianceGenome:SGD:S000001007; FungiDB:YHL015W; VEuPathDB:YHL015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    URP2
    Summary
    Enables mRNA binding activity. Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Part of cytosolic small ribosomal subunit. Used to study Diamond-Blackfan anemia. Orthologous to human RPS20 (ribosomal protein S20). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RPS20 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (75412..75777)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Dur3p Neighboring gene uncharacterized protein Neighboring gene Ylf2p Neighboring gene Otu2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of yeast RNA polymerase III mutations by the URP2 gene encoding a protein homologous to the mammalian ribosomal protein S20. Hermann-Le Denmat S, et al. J Mol Biol, 1994 Jul 1. PMID 8021936
    2. Expansion of germline RPS20 mutation phenotype to include Diamond-Blackfan anemia. Bhar S, et al. Hum Mutat, 2020 Nov. PMID 32790018, Free PMC Article
    3. Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains. Walker SE, et al. RNA, 2013 Feb. PMID 23236192, Free PMC Article
    4. Ribosome biogenesis factor Ltv1 chaperones the assembly of the small subunit head. Collins JC, et al. J Cell Biol, 2018 Dec 3. PMID 30348748, Free PMC Article
    5. The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Higgins R, et al. Mol Cell, 2015 Jul 2. PMID 26051182, Free PMC Article

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The 7-repeats and an N-terminal domain of yeIF4B (NTD) are the most critical domains, which mediate binding of yeIF4B to the head of the 40S ribosomal subunit via interaction with Rps20.
      Title: Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domains.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic small ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic small ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal 40S subunit protein S20
    NP_011848.1
    • Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; homologous to mammalian ribosomal protein S20 and bacterial S10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      75412..75777
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179095.1 → NP_011848.1  TPA: ribosomal 40S subunit protein S20 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011848.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKP7, P38701
      UniProtKB/TrEMBL
      A6ZSN7, B3LSA4, B5VJR5, C7GIS2, C8ZA51, G2WF52, N1P333
      Conserved Domains (1) summary
      cl00314
      Location:23 → 118
      Ribosomal_S10; Ribosomal protein S10p/S20e
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38701.3

    Gene LinkOut

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