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    SAP4 Sap4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852622, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SAP4
    Official Full Name
    Sap4p
    Primary source
    SGD:S000003198
    Locus tag
    YGL229C
    See related
    AllianceGenome:SGD:S000003198; FungiDB:YGL229C; VEuPathDB:YGL229C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein phosphatase regulator activity. Involved in G1/S transition of mitotic cell cycle. Located in mitochondrion. Orthologous to human PPP6R1 (protein phosphatase 6 regulatory subunit 1); PPP6R2 (protein phosphatase 6 regulatory subunit 2); and PPP6R3 (protein phosphatase 6 regulatory subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SAP4 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (64503..66959, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene chaperone EMC4 Neighboring gene uncharacterized protein Neighboring gene She10p Neighboring gene glucose-induced degradation complex subunit VID30

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors. Rohde JR, et al. Mol Cell Biol, 2004 Oct. PMID 15367655, Free PMC Article
    2. Saccharomyces cerevisiae ER membrane protein complex subunit 4 (EMC4) plays a crucial role in eIF2B-mediated translation regulation and survival under stress conditions. Sharma S, et al. J Genet Eng Biotechnol, 2020 Jun 1. PMID 32476094, Free PMC Article
    3. The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase. Luke MM, et al. Mol Cell Biol, 1996 Jun. PMID 8649382, Free PMC Article
    4. Distinct subsets of Sit4 holophosphatases are required for inhibition of Saccharomyces cerevisiae growth by rapamycin and zymocin. Jablonowski D, et al. Eukaryot Cell, 2009 Nov. PMID 19749176, Free PMC Article
    5. The serine/threonine protein phosphatase Sit4p activates multidrug resistance in Saccharomyces cerevisiae. Miranda MN, et al. FEMS Yeast Res, 2010 Sep. PMID 20608983

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Sap4p
    NP_011285.1
    • Protein required for function of the Sit4p protein phosphatase; member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p; SAP4 has a paralog, SAP155, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      64503..66959 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181095.1 → NP_011285.1  TPA: Sap4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011285.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVA5, P53036
      UniProtKB/TrEMBL
      A6ZTW1
      Conserved Domains (1) summary
      pfam04499
      Location:207 → 736
      SAPS; SIT4 phosphatase-associated protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53036.1

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