ADK2 adenylate kinase ADK2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ADK2
Official Full Name: adenylate kinase ADK2
Primary source: SGD:S000000972
Locus tag: YER170W
See related: AllianceGenome:SGD:S000000972; FungiDB:YER170W; VEuPathDB:YER170W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: AKY3; PAK3
Summary: Enables nucleoside triphosphate adenylate kinase activity. Involved in nucleotide metabolic process. Located in mitochondrial inner membrane. Is active in mitochondrial matrix. Orthologous to several human genes including AK4 (adenylate kinase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ADK2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (525974..526651)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the modified C-terminal domain in Adk2p (long) is not essential for enzyme activity, but it contributes to and strengthens protein folding and/or stability and is particularly important for maintaining enzyme activity under stress conditions
Title: A GTP:AMP phosphotransferase, Adk2p, in Saccharomyces cerevisiae. Role of the C terminus in protein folding/stabilization, thermal tolerance, and enzymatic activity.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables adenylate kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate adenylate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleoside triphosphate adenylate kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables nucleoside triphosphate adenylate kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in AMP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in AMP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in GTP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in ITP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nucleoside monophosphate phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in nucleoside triphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: adenylate kinase ADK2

NP_011097.3

EC 2.7.4.10

Mitochondrial adenylate kinase; catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

525974..526651

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179060.3 → NP_011097.3 TPA: adenylate kinase ADK2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011097.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DM78, E9P974, P26364

UniProtKB/TrEMBL

G2WD56, N1P792

Conserved Domains (1) summary

PRK00279
Location:21 → 216

adk; adenylate kinase; Reviewed