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    YDC1 alkaline dihydroceramidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856018, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YDC1
    Official Full Name
    alkaline dihydroceramidase
    Primary source
    SGD:S000006008
    Locus tag
    YPL087W
    See related
    AllianceGenome:SGD:S000006008; FungiDB:YPL087W; VEuPathDB:YPL087W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables N-acylsphingosine amidohydrolase activity. Involved in ceramide biosynthetic process and ceramide catabolic process. Located in endoplasmic reticulum. Used to study leukodystrophy. Orthologous to human ACER3 (alkaline ceramidase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YDC1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (383455..384408)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rlm1p Neighboring gene aldo-keto reductase superfamily protein Neighboring gene Elongator subunit ELP3 Neighboring gene Sec16p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast. Aerts AM, et al. Cell Mol Life Sci, 2008 Jun. PMID 18500447, Free PMC Article
    2. Cloning and characterization of a Saccharomyces cerevisiae alkaline ceramidase with specificity for dihydroceramide. Mao C, et al. J Biol Chem, 2000 Oct 6. PMID 10900202
    3. Molecular cloning and characterization of OsCDase, a ceramidase enzyme from rice. Pata MO, et al. Plant J, 2008 Sep. PMID 18547394, Free PMC Article
    4. Suppressor analysis points to the subtle role of the LAG1 ceramide synthase gene in determining yeast longevity. Jiang JC, et al. Exp Gerontol, 2004 Jul. PMID 15236759
    5. Identification of a novel amidase motif in neutral ceramidase. Galadari S, et al. Biochem J, 2006 Feb 1. PMID 16229686, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ceramides of ypc1ydc1 remained normal even in presence of aureobasidin A, an inhibitor of inositolphosphorylceramide synthase.
      Title: Characterization of yeast mutants lacking alkaline ceramidases YPC1 and YDC1.
    2. Overexpression of YDC1 results in reduced chronological lifespan and increased apoptotic cell death.
      Title: Ydc1p ceramidase triggers organelle fragmentation, apoptosis and accelerated ageing in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables N-acylsphingosine amidohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acylsphingosine amidohydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in ceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ceramide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alkaline dihydroceramidase
    NP_015238.1
    • Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity; YDC1 has a paralog, YPC1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      383455..384408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183901.1 → NP_015238.1  TPA: alkaline dihydroceramidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015238.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3T0, Q02896
      UniProtKB/TrEMBL
      A6ZWG4, B3LKY5, B5VT78, C7GVE7, C8ZIU3, G2WP94, N1NW36
      Conserved Domains (1) summary
      pfam05875
      Location:14 → 285
      Ceramidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02896.1

    Gene LinkOut

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