MEX67 Mex67p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: MEX67
Official Full Name: Mex67p
Primary source: SGD:S000006090
Locus tag: YPL169C
See related: AllianceGenome:SGD:S000006090; FungiDB:YPL169C; VEuPathDB:YPL169C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables porin activity; snRNA binding activity; and tRNA binding activity. Involved in nuclear export and tRNA processing. Located in cytoplasm. Part of nuclear RNA export factor complex and nuclear pore. Is active in nucleus. Orthologous to several human genes including NXF1 (nuclear RNA export factor 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MEX67 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 1

Sequence:: Chromosome: XVI; NC_001148.4 (229039..230838, complement)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm7 complex.
Title: Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm(7) complex.
Dbp5 associates with RNA-bound Mex67 and Nab2 and its localization at the nuclear pore complex is sufficient for mRNP export and cell viability.
Title: Dbp5 associates with RNA-bound Mex67 and Nab2 and its localization at the nuclear pore complex is sufficient for mRNP export and cell viability.
Mex67 functions as a mobile nuclear pore complex (NPC) component, which receives mRNA export substrates in the central channel of the NPC to facilitate their translocation to the cytoplasm; this interaction is not affected by Dbp5, which is thought to remove Mex67 from transcripts
Title: The RNA export factor Mex67 functions as a mobile nucleoporin.
Mex67-Mtr2 functions in primary nuclear export for a subset of yeast tRNAs
Title: Sharing the load: Mex67-Mtr2 cofunctions with Los1 in primary tRNA nuclear export.
This study describes the mechanism of recruitment of the Saccharomyces cerevisiae RNA-export receptor Mex67-Mtr2 to the pre-60S subunit at the proper time. Mex67-Mtr2 binds at the premature ribosomal-stalk region, which later during translation serves as a binding platform for translational GTPases on the mature ribosome.
Title: Ribosome-stalk biogenesis is coupled with recruitment of nuclear-export factor to the nascent 60S subunit.
show that the NTF2-like domain from Saccharomyces cerevisiae Mex67:Mtr2 also contributes to RNA binding
Title: Domain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surface.
Thus Mex67-Mtr2 is a unique transport receptor that employs a common interaction surface to participate in the nuclear export of both pre-ribosomal subunits and mRNAs
Title: Role of Mex67-Mtr2 in the nuclear export of 40S pre-ribosomes.
Data indicate that Edc3p-mediated YRA1 pre-mRNA decay occurs independently of translation and also requires Mex67p.
Title: Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p.
mutant Mex67-5p, but not wild-type Mex67p, is a target of the nuclear protein quality control mediated by San1p, a ubiquitin-protein ligase that participates in degradation of aberrant chromatin-associated proteins
Title: A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor.
Nap1 interacts with the mRNA export factor Mex67.
Title: Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U1 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U2 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U4 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U5 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables U6 snRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	HDA more info	PubMed
enables porin activity	IDA Inferred from Direct Assay more info	PubMed
enables tRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in poly(A)+ mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit export from nucleus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ribosomal large subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tRNA re-export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of nuclear RNA export factor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mex67p

NP_015156.1

Poly(A) RNA binding protein involved in nuclear mRNA export; component of the nuclear pore and nuclear RNA export factor; ubiquitin-associated (UBA) domain interacts with Mip6p; ortholog of human TAP

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

229039..230838 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183983.1 → NP_015156.1 TPA: Mex67p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015156.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3J9, Q99257

UniProtKB/TrEMBL

B3LKQ9, C7GJC0, C8ZIK9, N1NWZ9

Conserved Domains (4) summary

smart00804
Location:537 → 597

TAP_C; C-terminal domain of vertebrate Tap protein

sd00035
Location:119 → 163

LRR_NTF; leucine-rich repeat [structural motif]

pfam18444
Location:23 → 92

RRM_9; RNA recognition motif

cd21340
Location:155 → 256

PPP1R42; protein phosphatase 1 regulatory subunit 42